Sulfo-EMCS (N-ε-maleimidocaproyl-oxysulfosuccinimide ester)

Catalog number: 22307

Thermo Scientific™  Related applications: Protein Labeling & Crosslinking

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Thermo Scientific Pierce Sulfo-EMCS is a water-soluble amine-to-sulfhydryl crosslinker that contains NHS-ester and maleimide reactive groups at opposite ends of a medium-length spacer arm (9.4 angstroms).

Features of Sulfo-EMCS:

Reactive groups: sulfo-NHS ester and maleimide
Reactive towards: amino and sulfhydryl groups
• Sulfo-NHS ester end couples with primary amines at pH 7-9 to form stable amide bonds
• Maleimide reacts with -SH groups at pH 6.5-7.5, forming stable thioether linkages
• Non-cleavable
• Water-soluble (compare to EMCS)
• Aliphatic spacer offers low potential for eliciting an immune response

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

Related Products
EMCS (N-ε-malemidocaproyl-oxysuccinimide ester)
For Research Use Only. Not for use in diagnostic procedures.


Spacer: Short
Solubility: Water
Product Size: 50 mg
Labeling Method: Chemical Labeling
Crosslinker Type: Heterobifunctional

Contents & storage

Upon receipt store desiccated at 4° C. Product is shipped at ambient temperature.


Manuals & protocols