Thermo Scientific™

Pierce™ MMTS (methyl methanethiosulfonate)

Catalog number:  23011

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce MMTS (methyl methanethiosulfonate) is a small compound that reversibly blocks cysteines and other sulfhydryl groups, enabling the study of enzyme activation and other protein functions.

Features of MMTS (methyl methanethiosulfonate):

• Converts sulfhydryl groups on cysteine side chains into -S-S-CH3
• Reaction is reversible with DTT or TCEP, restoring the free sulfhydryl
• Used to modify thiol groups in creatine kinase

MMTS (methyl methanethiosulfonate) is a sulfhydryl-reactive compound that can reversibly sulfenylate thiol-containing molecules. Reacting MMTS with reduced sulfhydryls (-SH) results in their modification to dithiomethane (-S-S-CH3). Treatment with reducing agents, such as dithiothreitol (DTT), 2-mercaptoethanol (2-ME) or Tris(2-carboxyethyl) phosphine hydrochloride (TCEP), will cleave the disulfide groups to restore the original sulfhydryl. MMTS is commonly used to study biochemical pathways involving thiol-dependent enzymes.

More Product Data
Specific labeling, enrichment and quantitation of S-nitrosylated peptides using iodoTMT reagents

Related Products
Pierce™ NEM (N-ethylmaleimide)
For Research Use Only. Not for use in diagnostic procedures.


Chemical Reactivity: Thiol
Label or Dye: Unreactive Group
Product Line: Pierce™
Product Size: 200 mg

Contents & storage

Upon receipt store at 4°C.


Manuals & protocols