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NeoBiotechnologies

FOXO1 (Forkhead box O1) (Transcription Factor) Monoclonal Antibody (FOXO1/9792)

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FOXO1 (Forkhead box O1) (Transcription Factor) Monoclonal Antibody (FOXO1/9792)

Product Details

2308-MSM2-P1ABX

Applications
Tested Dilution
Publications

Western Blot (WB)

2-4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

FOXO1/9792

Immunogen

Recombinant fragment (around aa 450-650) of human FOXO1 protein (exact sequence is proprietary).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

FOXO1 (FKHR, ForKHead Box 01) is a member in a subfamily of the forkhead homeotic gene family of transcription factors. Recent experiments have shown that FOXO1 can act as either a coactivator or a corepressor of nuclear receptor activity that is mediated through the LXXLL motif found in the carboxyl terminal region of the FKHR protein. Association of FOXO1 with PAX3 has been implicated in alveolar rhabdomyosarcoma. Recent studies link the anti-tumor activity of FOXO1, the process of autophagy and myogenic growth and differentiation. FOXO1 is the main target of insulin signaling that regulated the metabolic homeostasis in response to oxidative stress. FOXO1 binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'- TT[G/A]TTTAC-3'. FOXO1 is a regulator of redox balance, osteoblast numbers and controls bone mass. Further, FOXO1 orchestrates the endocrine function of the skeleton in regulating glucose metabolism, and suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, FOXO1 promotes gluconeogenesis by acting together with PPARGC1A to activate the expression of genes such as IGFBP1, G6PC and PPCK1. FOXO1 is an important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Forkhead box protein O1; Forkhead box protein O1A; Forkhead in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; FOX01A

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Gene Aliases: FKH1; FKHR; FOXO1; FOXO1A

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UniProt ID: (Human) Q12778

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Entrez Gene ID: (Human) 2308

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding protein phosphatase 2A binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel development temperature homeostasis cellular glucose homeostasis gluconeogenesis regulation of gluconeogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter protein acetylation autophagy apoptotic process cellular response to DNA damage stimulus insulin receptor signaling pathway cellular response to starvation gene expression positive regulation of autophagy cell differentiation response to insulin cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade positive regulation of smooth muscle cell apoptotic process cellular response to oxidative stress regulation of cell proliferation glucose homeostasis positive regulation of apoptotic process negative regulation of apoptotic process fat cell differentiation negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of insulin secretion canonical Wnt signaling pathway regulation of transcription initiation from RNA polymerase II promoter cellular response to cold response to fatty acid cellular response to hyperoxia cellular response to nitric oxide negative regulation of canonical Wnt signaling pathway energy homeostasis neuronal stem cell population maintenance negative regulation of cardiac muscle hypertrophy in response to stress regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process
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