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Proteintech
KCNQ3 Polyclonal Antibody
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Product Details
24580-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KCNQ3 fusion protein Ag20147
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Amount
67.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: PNRIDLVATW RFYESVVSFP FFRKEQLEAA SSQKLGLLDR VRLSNPRGSN TKGKLFTPLN VDAIEESPSK EPKPVGLNNK ERFRTAFRMK AYAFWQSSED AGTGDPMAED RGYGNDFPIE DMIPTLKAAI RAVRILQFR
Target Information
KCNQs are members of the voltage-dependent non-inactivating potassium channel family. Currently there are five known KCNQs (KCNQ1-5) found in the central nervous system and KCNQ2 and 3 have demonstrated their importance in M-current activation. Studies have shown that KCNQ2 and KCNQ3 form heteromultimers that, when formed, substantially increase the M-current. Inhibition of M-current controls neuron excitability throughout the nervous system as well as the responsiveness to synaptic inputs. Genetic mutations in these proteins have been linked to disorders such as benign familial neonatal convulsions (BFNC), deafness, neuropathic pain and epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BFNC; KQT-like 3; Potassium channel subunit alpha KvLQT3; potassium channel, voltage gated KQT-like subfamily Q, member 3; potassium channel, voltage-gated, subfamily Q, member 3; Potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; potassium voltage-gated channel, subfamily Q, member 3; unnamed protein product; Voltage-gated potassium channel subunit Kv7.3
Gene Aliases: BFNC2; EBN2; KCNQ3; KV7.3
UniProt ID: (Human) O43525, (Rat) O88944, (Mouse) Q8K3F6
Entrez Gene ID: (Human) 3786, (Rat) 29682, (Mouse) 110862
ion channel activity
voltage-gated ion channel activity
voltage-gated potassium channel activity
potassium channel activity
protein binding
calmodulin binding
voltage-gated cation channel activity
delayed rectifier potassium channel activity
protein kinase binding
ubiquitin protein ligase binding
ion channel binding
voltage-gated ion channel
protein targeting
protein import into nucleus
ion transport
potassium ion transport
exocytosis
endocytosis
chemical synaptic transmission
sensory perception of sound
response to mechanical stimulus
gene expression
response to auditory stimulus
protein transport
neuron remodeling
neuronal action potential
nerve development
neuron differentiation
ion transmembrane transport
psychomotor behavior
regulation of synaptic plasticity
neuron apoptotic process
establishment of localization in cell
mitochondrial depolarization
transmembrane transport
membrane hyperpolarization
protein-containing complex assembly
cellular response to calcium ion
cellular response to xenobiotic stimulus
potassium ion transmembrane transport
apoptosome assembly
excitatory chemical synaptic transmission
inhibitory chemical synaptic transmission
action potential initiation
regulation of action potential firing threshold
substantia propria of cornea development
oligodendrocyte development
regulation of ion transmembrane transport
ganglion development
cellular response to ammonium ion
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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