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Proteintech
ATG2B Polyclonal Antibody
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Product Details
25155-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATG2B Fusion Protein Ag18412 (1304-1555 aa encoded by BC015016)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RDYVRVMDM GLLELTITAV KSDSDGEQTE PRFELHCSSD VVHIRTCSDS CAALMNLIQY IASYGDLQTP NKADMKPGAF QRRSKVDSSG RSSSRGPVLP EADQQMLRDL MSDAMEEIDM QQGTSSVKPQ ANGVLDEKSQ IQEPCCSDLF LFPDESGNVS QESGPTYASF SHHFISDAMT GVPTENDDFC ILFAPKAAMQ EKEEEPVIKI MVDDAIVIRD NYFSLPVNKT DTSKAPLHFP IPVIRYVVKE VS (1304-1555 aa encoded by B C015016)
Target Information
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATG2 autophagy related 2 homolog B; Autophagy-related protein 2 homolog B; bridge-like lipid transfer protein family member 4B; unnamed protein product
Gene Aliases: ATG2B; BLTP4B; C14orf103
UniProt ID: (Human) Q96BY7
Entrez Gene ID: (Human) 55102
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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