Thermo Scientific™

CT(PEG)12 Carboxy-PEG-Thiol Compound

Catalog number:  26133

 Related applications:

Protein Labeling & Crosslinking

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Thermo Scientific Pierce CT(PEG)12, or carboxy-PEG12-thiol, is a carboxyl- and sulfhydryl-terminated compound that contains a 12-unit polyethylene glycol (PEG) spacer and is used to modify surfaces such as quantum dots, monolayers and magnetic particles.

CT(PEG)12 is monodentate thiol-terminated and carboxylic acid pegylation reagent. The PEG compound has a defined molecular weight and spacer length and is useful for modifying surfaces such quantum dots, self-assembled monolayers and magnetic particles. Functionalization of solid surfaces with this polyethylene glycol reagent provides carboxylate "handles" for protein immobilization via EDC crosslinking and significantly reduces nonspecific protein binding and provides.

Features of carboxy-PEG12-thiol:

Metal-binding—terminal monodentate thiol reacts spontaneously with gold surfaces through dative binding
Carboxylate—terminal carboxylic acid group allows conjugation to amine-containing affinity ligands using carbodiimide (EDC) and Sulfo-NHS crosslinking chemistry
Polyethylene glycol—PEG groups are flexible, non-immunogenic, hydrophilic, and significantly reduce nonspecific binding of surfaces for protein methods
Spacer arm—12-unit PEG spacer is nearly 48 angstroms long, minimizing steric hindrance for protein immobilization and binding assays

The use of MT(PEG)4 with CT(PEG)12 in surface modification can form a hydrophilic "lawn" of methyl ether-terminated PEGs with periodic exposed carboxylic acid-containing PEGs. The exposed carboxylic acid groups can be coupled to affinity ligands using the carbodiimide coupling reaction with EDC and sulfo-NHS.

Related Products
CL(PEG)12 Carboxy-PEG-Lipoamide Compound
For Research Use Only. Not for use in diagnostic procedures.


Chemical Reactivity: Amine, Metal Surface
Product Size: 100 mg

Contents & storage

Store at -20°C protected from moisture. Shipped at ambient temperature.


Manuals & protocols