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          • Primary Antibodies ›
          • FGFR1 Antibodies

          QED Bioscience

          FGF Receptor-alpha Monoclonal Antibody (M2F12)

          View all (64) FGFR1 antibodies

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          Cite FGF Receptor-alpha Monoclonal Antibody (M2F12)

          Additional Information:
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          FGF Receptor-alpha Monoclonal Antibody (M2F12)

          Product Details

          30104-250UG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1 µg/mL
          -

          Immunohistochemistry (Frozen) (IHC (F))

          Assay-dependent
          -

          Immunoprecipitation (IP)

          1 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Mouse / IgG2a

          Class

          Monoclonal

          Type

          Antibody

          Clone

          M2F12

          Immunogen

          Recombinant human ectodomain of FGFr1 alpha expressed in E. coli beginning with pro23; antigen contained NH2-terminal gly-ser-pro-gly-ile and COOH-terminal glu-phe sequences.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.5-1.0 mg/mL

          Amount

          250 µg

          Purification

          Protein A

          Storage buffer

          PBS, pH 7.4

          Contains

          no preservative

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that constitute a family of four membrane-spanning tyrosine kinases (FGFR1-4) which serve as high-affinity receptors for 17 growth factors (FGF1-17). The FGF Receptor family plays an important role in multiple biological processes, including mesoderm induction and patterning, cell growth and migration, organ formation and bone growth. FGFR1 is alternatively spliced generating multiple splice variants that are differentially expressed during embryo development and in the adult body. Other defects in FGFR1 are responsible for several diseases which include Pfeiffer syndrome (PS), idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, Antley-Bixler syndrome. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: 2.7.10.1; Basic fibroblast growth factor receptor 1; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD331 antigen; FGF Receptor; FGF receptor-1; FGF receptor-1 precursor; FGFR; fgfr 1; FGFR-1; FGFR1/PLAG1 fusion; fibroblast growth factor receptor (FGFr) transmembrane form; Fibroblast growth factor receptor 1; fibroblast growth factor receptor FGFR-1 secreted form; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; MFR; N-sam; Proto-oncogene c-Fgr; unnamed protein product

          View more View less

          Gene Aliases: AW208770; bFGF-R-1; BFGFR; c-fgr; CD331; CEK; Eask; ECCL; FGFBR; FGFR-1; FGFR1; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; Hspy; KAL2; MFR; N-SAM; OGD

          View more View less

          UniProt ID: (Human) P11362, (Rat) Q04589, (Mouse) P16092

          View more View less

          Entrez Gene ID: (Human) 2260, (Rat) 79114, (Mouse) 14182

          View more View less

          Function(s)
          nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity fibroblast growth factor-activated receptor activity protein binding ATP binding heparin binding kinase activity transferase activity fibroblast growth factor binding SH2 domain binding identical protein binding protein homodimerization activity receptor-receptor interaction glycoprotein binding protein complex binding cell adhesion molecule binding transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade skeletal system development angiogenesis ureteric bud development in utero embryonic development organ induction neuron migration epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation chondrocyte differentiation protein phosphorylation brain development salivary gland morphogenesis sensory perception of sound cell proliferation positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway mesenchymal cell proliferation gene expression regulation of gene expression positive regulation of phospholipase activity positive regulation of macromolecule metabolic process negative regulation of gene expression regulation of phosphate transport positive regulation of neuron projection development cell migration peptidyl-tyrosine phosphorylation orbitofrontal cortex development ventricular zone neuroblast division cell projection assembly lung development embryonic limb morphogenesis midbrain development neuron projection development fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development inner ear morphogenesis outer ear morphogenesis middle ear morphogenesis chordate embryonic development positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of blood vessel endothelial cell migration ear development cellular response to fibroblast growth factor stimulus regulation of cell differentiation positive regulation of cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle protein autophosphorylation phosphatidylinositol-mediated signaling paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation blood vessel morphogenesis generation of neurons skeletal system morphogenesis mesenchymal cell differentiation stem cell differentiation regulation of epithelial cell proliferation regulation of phosphorus metabolic process positive regulation of protein kinase B signaling calcium ion homeostasis cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation auditory receptor cell development branching involved in salivary gland morphogenesis lung-associated mesenchyme development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling vitamin D3 metabolic process diphosphate metabolic process cementum mineralization stem cell proliferation regulation of primary metabolic process positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway negative regulation of fibroblast growth factor production regulation of postsynaptic density assembly positive regulation of mitotic cell cycle DNA replication response to sodium phosphate positive regulation of vascular endothelial cell proliferation positive regulation of stem cell proliferation positive regulation of parathyroid hormone secretion positive regulation of endothelial cell chemotaxis regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of phospholipase C activity stem cell population maintenance motogenic signaling involved in postnatal olfactory bulb interneuron migration central nervous system neuron development regulation of cell proliferation negative regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter regulation of sensory perception of pain regulation of stem cell proliferation phosphorylation vasculogenesis involved in coronary vascular morphogenesis
          It has to be done as per old AB suggested Products section.

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