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Invitrogen
alpha Synuclein Monoclonal Antibody (Syn 211)
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FIGURE: 1 / 40
alpha Synuclein Antibody (32-8100) in WB
Western blot was performed using Anti-alpha Synuclein Monoclonal Antibody (Syn 211) (Product # 32-8100) and a 14 kDa band corresponding to alpha Synuclein was observed across the cell lines tested. Membrane enriched extracts (30 µg lysate) of HEK-293 (Lane 1), HEL 92.1.7 (Lane 2), Hep G2 (Lane 3), A-549 (Lane 4), Jurkat (Lane 5) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Produ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
32-8100
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Bacteria,
Human,
Mouse,
Non-human primate,
Rat,
Rhesus monkey
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
Syn 211
Immunogen
Recombinant human alpha-synuclein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody reacts with the alpha-synuclein protein. This antibody does not cross-react with beta- or gamma-synuclein or synoretin. During development reactivity was confirmed with human. Reactivity with other species has not been tested.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Alpha synuclein; Alpha-synuclein; NACP; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor
Gene Aliases: NACP; PARK1; SNCA
Entrez Gene ID: (Human) 6622
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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