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NeoBiotechnologies
HSP60 (Heat Shock Protein 60) Recombinant Mouse Monoclonal Antibody (rGROEL, 780)
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Product Details
3329-MSM7-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
rGROEL, 780
Immunogen
Recombinant full-length human HSP60 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
This antibody does not react with bacteria, Helminths or Spinach.
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 60 kDa chaperonin; 60 kDa heat shock protein; 60 kDa heat shock protein, mitochondrial; chaperonin; chaperonin (HSP60); Chaperonin 60; CPN60; epididymis secretory sperm binding protein; heat shock 60kDa protein 1 (chaperonin); heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_1; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_2; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_4; Heat shock protein; Heat shock protein 60; heat shock protein 65; Heat shock protein family D member 1; heat shock protein, 60 kDa; HSP; HSP-60; HSP-65; Hsp60s1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1; unnamed protein product
Gene Aliases: 60kDa; CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HSPD1; HuCHA60; SPG13
UniProt ID: (Human) P10809, (Mouse) P63038
Entrez Gene ID: (Human) 3329, (Mouse) 15510
nucleotide binding
lipopolysaccharide binding
p53 binding
DNA replication origin binding
single-stranded DNA binding
RNA binding
double-stranded RNA binding
protein binding
ATP binding
high-density lipoprotein particle binding
isomerase activity
ATPase activity
enzyme binding
ubiquitin protein ligase binding
apolipoprotein binding
apolipoprotein A-I binding
unfolded protein binding
chaperone binding
cysteine-type endopeptidase activator activity
ATP-dependent protein folding chaperone
protease binding
protein complex binding
insulin binding
poly(A) RNA binding
protein heterodimerization activity
misfolded protein binding
positive regulation of cytokine production
MyD88-dependent toll-like receptor signaling pathway
positive regulation of T cell mediated immune response to tumor cell
protein folding
'de novo' protein folding
response to unfolded protein
apoptotic mitochondrial changes
response to cold
positive regulation of interferon-alpha production
positive regulation of interferon-gamma production
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
mitochondrial unfolded protein response
protein refolding
B cell proliferation
T cell activation
B cell activation
positive regulation of macrophage activation
negative regulation of apoptotic process
adhesion of symbiont to host
protein import into mitochondrial intermembrane space
isotype switching to IgG isotypes
protein stabilization
positive regulation of T cell activation
chaperone-mediated protein complex assembly
protein maturation
interaction with symbiont
cellular response to interleukin-7
negative regulation of execution phase of apoptosis
positive regulation of execution phase of apoptosis
detection of misfolded protein
B cell cytokine production
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of apoptotic process
negative regulation of neuron apoptotic process
positive regulation of inflammatory response
chaperone mediated protein folding requiring cofactor
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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