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Invitrogen
ROC1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
34-2500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Virus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
specific to Human ROC1C
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein transferase RBX1; RBX1; regulator of cullins 1; RING finger protein 75; ring-box 1, E3 ubiquitin protein ligase; RING-box protein 1; unnamed protein product; ZYP protein
Gene Aliases: 1500002P15Rik; BA554C12.1; RNF75; ROC1
UniProt ID: (Human) P62877, (Mouse) P62878
Entrez Gene ID: (Human) 9978, (Mouse) 56438
ubiquitin-protein transferase activity
protein binding
zinc ion binding
NEDD8 transferase activity
ubiquitin protein ligase binding
ubiquitin-ubiquitin ligase activity
binding, bridging
RNA polymerase II sequence-specific DNA binding transcription factor binding
ubiquitin protein ligase activity
NEDD8 ligase activity
cullin family protein binding
eukaryotic initiation factor 4E binding
macromolecular complex binding
G1/S transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
protein polyubiquitination
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
protein monoubiquitination
cellular iron ion homeostasis
cellular response to DNA damage stimulus
spermatogenesis
regulation of mitotic cell cycle
cell proliferation
regulation of autophagy
regulation of cell cycle process
regulation of centrosome duplication
neural crest cell differentiation
protein processing
protein ubiquitination
regulation of DNA-dependent DNA replication initiation
regulation of BMP signaling pathway
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
replication fork processing
regulation of TOR signaling
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of type I interferon production
regulation of natural killer cell activation
cellular response to oxidative stress
cellular response to UV
regulation of gene expression, epigenetic
T cell activation
regulation of cell proliferation
regulation of circadian rhythm
signal transduction in response to DNA damage
regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
post-translational protein modification
protein K27-linked ubiquitination
protein neddylation
positive regulation of cilium assembly
positive regulation of protein catabolic process
negative regulation of smoothened signaling pathway
regulation of embryonic development
negative regulation of insulin receptor signaling pathway
regulation of inflammatory response
centrosome duplication
regulation of cell cycle
limb development
cilium morphogenesis
regulation of gene silencing by miRNA
cellular response to chemical stress
protein K63-linked ubiquitination
protein K48-linked ubiquitination
cellular response to amino acid stimulus
regulation of cellular response to stress
negative regulation of canonical Wnt signaling pathway
ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
RNA polymerase II transcription initiation surveillance
negative regulation of beige fat cell differentiation
regulation of cellular response to insulin stimulus
regulation of mitophagy
negative regulation of macromitophagy
regulation of cell cycle phase transition
regulation of mitotic cytokinesis
positive regulation of protein autoubiquitination
negative regulation of response to oxidative stress
negative regulation of adipose tissue development
positive regulation of TORC1 signaling
regulation of xenophagy
ribosome-associated ubiquitin-dependent protein catabolic process
regulation of DNA damage checkpoint
regulation of stem cell population maintenance
negative regulation of DNA-dependent DNA replication
autophagosome assembly
mitophagy
epithelial to mesenchymal transition
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
apoptotic process
response to oxidative stress
lysosome organization
insulin receptor signaling pathway
negative regulation of autophagy
positive regulation of autophagy
protein catabolic process
DNA damage response, signal transduction by p53 class mediator
cellular response to nutrient levels
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of type I interferon production
cellular response to insulin stimulus
cellular response to amino acid starvation
mRNA cleavage involved in gene silencing by miRNA
p38MAPK cascade
TORC1 signaling
positive regulation of translation
positive regulation of transcription from RNA polymerase II promoter
type I interferon signaling pathway
base-excision repair, AP site formation via deaminated base removal
negative regulation of signal transduction by p53 class mediator
positive regulation of epithelial cell apoptotic process
negative regulation of TORC1 signaling
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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