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NeoBiotechnologies
Arginase 1 (Hepatocellular Carcinoma Marker) Monoclonal Antibody (ARG1/9446)
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Product Details
383-MSM16-P1ABX
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
ARG1/9446
Immunogen
Recombinant fragment (around aa 1-200) of human ARG1 protein(exact sequence is proprietary).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A-I; Arginase; arginase (EC 3.5.3.1); arginase 1 liver; arginase, liver; Arginase-1; Arginase1; HGNC:663; Liver Arginase; Liver-type arginase; Type 1 Arginase; Type I arginase
Gene Aliases: ARG1
UniProt ID: (Human) P05089
Entrez Gene ID: (Human) 383
urea cycle
adaptive immune response
immune system process
arginine metabolic process
arginine catabolic process
response to nematode
regulation of cell proliferation
negative regulation of T cell proliferation
defense response to protozoan
innate immune response
negative regulation of activated T cell proliferation
negative regulation of interferon-gamma-mediated signaling pathway
positive regulation of neutrophil mediated killing of fungus
negative regulation of T-helper 2 cell cytokine production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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