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Invitrogen
AKT2 Monoclonal Antibody (ZA006)
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FIGURE: 1 / 3
AKT2 Antibody (39-3900) in IHC (P)
Immunohistochemistry analysis of AKT2 showing staining in the cytoplasm of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10 mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, wa... View More
Product Details
39-3900
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
ZA006
Immunogen
Synthetic peptide derived from the C-terminal region of the human Akt2 protein, which is 95% and 90% homologous with rat and mouse, respectively
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
AKT2 is a phosphoinositide-dependent serine/threonine protein kinase that is enriched in insulin responsive tissues and has been implicated in the metabolic actions of the hormone. Akt is involved in many cellular signaling pathways and acts as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI 3-kinase). Akt2 is amplified and overexpressed in some human cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AKT2 kinase; murine thymoma viral (v-akt) homolog-2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; putative v-akt murine thymoma viral oncoprotein 2; RAC protein kinase beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; unnamed protein product; v-akt murine thymoma viral oncogene homolog 2
Gene Aliases: AKT2; HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA
UniProt ID: (Human) P31751, (Rat) P47197
Entrez Gene ID: (Human) 208, (Rat) 25233
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
molecular function activator activity
protein kinase C binding
non-receptor serine/threonine protein kinase
glycogen metabolic process
glycogen biosynthetic process
glucose metabolic process
regulation of translation
apoptotic process
signal transduction
insulin receptor signaling pathway
negative regulation of plasma membrane long-chain fatty acid transport
positive regulation of glucose metabolic process
regulation of cell migration
positive regulation of cell migration
positive regulation of fatty acid beta-oxidation
peripheral nervous system myelin maintenance
cellular response to insulin stimulus
intracellular signal transduction
protein modification process
negative regulation of apoptotic process
positive regulation of blood vessel endothelial cell migration
fat cell differentiation
positive regulation of glycogen biosynthetic process
positive regulation of glucose import
protein stabilization
regulation of cell cycle
mammary gland epithelial cell differentiation
cellular response to high light intensity
protein localization to plasma membrane
positive regulation of protein targeting to membrane
retinal rod cell apoptotic process
positive regulation of cap-dependent translational initiation
negative regulation of PERK-mediated unfolded protein response
positive regulation of cell motility
positive regulation of protein phosphorylation
protein phosphorylation
response to osmotic stress
multicellular organism development
carbohydrate transport
positive regulation of signal transduction
positive regulation of gene expression
positive regulation of sodium ion transport
response to muscle activity
positive regulation of vesicle fusion
response to nutrient levels
response to insulin
cellular response to hormone stimulus
negative regulation of RNA splicing
positive regulation of peptidyl-serine phosphorylation
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
positive regulation of transcription from RNA polymerase II promoter
positive regulation of positive chemotaxis
intracellular protein transmembrane transport
cellular response to organic cyclic compound
positive regulation of glucose import in response to insulin stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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