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QED Bioscience
Phospho-Elk1 (Thr417) Polyclonal Antibody
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Product Details
43038-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence that includes phosphorylation site of threonine 417 (L-S-T(p)-P-V) derived from human Elk1 and conjugated to KLH.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
Dulbecco's PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors. ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus. Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1. ELK1 appears to be a direct target of activated MAP kinase. Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo. ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for ELK1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ELK 1; ELK1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene; unnamed protein product
Gene Aliases: Elk-1; ELK1
UniProt ID: (Human) P19419, (Mouse) P41969, (Rat) A4GTP4
Entrez Gene ID: (Human) 2002, (Mouse) 13712, (Rat) 314436
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
mediator complex binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
transcription regulator inhibitor activity
transcription regulator activator activity
sequence-specific double-stranded DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
winged helix/forkhead transcription factor
liver development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
response to light stimulus
gene expression
cell differentiation
lung development
response to ethanol
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cellular response to testosterone stimulus
cellular response to lipid
cellular response to gamma radiation
response to fibroblast growth factor
hippocampal neuron apoptotic process
transcription, DNA-templated
transcription from RNA polymerase II promoter
positive regulation of neuron death
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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