Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia.
AuthorsPantazopoulos H, Boyer-Boiteau A, Holbrook EH, Jang W, Hahn CG, Arnold SE, Berretta S
Journal
PubMed ID24035561
'Emerging evidence points to proteoglycan abnormalities in the pathophysiology of schizophrenia (SZ). In particular, markedly abnormal expression of chondroitin sulfate proteoglycans (CSPGs), key components of the extracellular matrix, was observed in the medial temporal lobe. CSPG functions, including regulation of neuronal differentiation and migration, are highly relevant to the pathophysiology ... More
Histopathological changes in the upper respiratory tract of F344 rats following infection with a rat-adapted influenza virus.
AuthorsIbanes JD, Morgan KT, Burleson GR
JournalVet Pathol
PubMed ID8817839
'The present study determined the morphogenesis of upper respiratory tract disease in rats following infection with a rat-adapted influenza virus. Sixty-eight 60-day-old, male F344 rats were infected by intranasal inoculation and necropsied at days 1, 2, 4, 7, 14, and 28 post-inoculation (PI). Responses to infection were studied by routine ... More
A locus control region adjacent to the human red and green visual pigment genes.
'Deletion of sequences 5'' of the human red and green pigment gene array results in blue cone monochromacy, a disorder in which both red and green cone function are absent. To test whether these sequences are required for transcription of the adjacent visual pigment genes in cone photoreceptors, we produced ... More
Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus.
AuthorsHunt JS, Vassmer D, Ferguson TA, Miller L
JournalJ Immunol
PubMed ID9126971
'Despite intimate juxtaposition of maternal and fetal tissues during mammalian pregnancy, reciprocal migration of cells is limited. To evaluate the postulate that cell traffic is restricted by expression of Fas ligand (FasL) in the uterus and placenta, FasL mRNA was identified by using reverse transcription-PCR, and FasL protein was identified ... More
The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectins ELAM-1 and GMP-140.
AuthorsPicker LJ, Warnock RA, Burns AR, Doerschuk CM, Berg EL, Butcher EC
JournalCell
PubMed ID1716182
'LECAM-1 (leukocyte-endothelial cell adhesion molecule 1), the lymphocyte lectin ("selectin") homing receptor for peripheral lymph nodes (PLNs), participates in the earliest interactions of polymorphonuclear neutrophilic leukocytes (PMNs) with inflamed venules. Here, we present evidence that LECAM-1 mediates this function through a novel mechanism--presentation of oligosaccharide ligands to the inducible vascular ... More
Serological responses to mycoplasmas in HIV-infected and non-infected individuals.
AuthorsHakkarainen K, Jansson E, Ranki A, Valle SL, Krohn KJ
JournalAIDS
PubMed ID1472333
To assess the frequency of mycoplasma infections in HIV-antibody-positive and -negative individuals by studying the serological responses against mycoplasmas, especially Mycoplasma fermentans and M. pirum.
The use of automated quantitative analysis to evaluate epithelial-to-mesenchymal transition associated proteins in clear cell renal cell carcinoma.
AuthorsO'Mahony FC, Faratian D, Varley J, Nanda J, Theodoulou M, Riddick AC, Harrison DJ, Stewart GD
JournalPLoS One
PubMed ID22363672
Epithelial-to-mesenchymal transition (EMT) has recently been implicated in the initiation and progression of renal cell carcinoma (RCC). Some mRNA gene expression studies have suggested a link between the EMT phenotype and poorer clinical outcome from RCC. This study evaluated expression of EMT-associated proteins in RCC using in situ automated quantitative ... More
Monoclonal antibody analysis of phosphatidylserine and protein kinase C localizations in developing rat cerebellum.
AuthorsMiyazawa A, Inoue H, Yoshioka T, Horikoshi T, Yanagisawa K, Umeda M, Inoue K
JournalJ Neurochem
PubMed ID1402903
Understanding the topographical relationships between phosphatidylserine (PS) and protein kinase C (PKC) within neurons can provide clues about the mechanism of translocation and activation of PKC. For this purpose we applied monoclonal antibodies (Abs) of PS and PKC to sections of developing rat cerebellum. The anti-PKC Ab immunohistochemical pattern showed ... More
A comparison of three immunoperoxidase techniques for antigen detection in colorectal carcinoma tissues.
AuthorsShi ZR, Itzkowitz SH, Kim YS
JournalJ Histochem Cytochem
PubMed ID3278057
We compared the streptavidin-peroxidase conjugate (SP) method of immunoperoxidase histochemistry to the unlabeled antibody (PAP) and avidin-biotin-peroxidase complex (ABC) techniques in human colorectal carcinoma tissues stained with a monoclonal antibody for expression of carcinoembryonic antigen. Compared to the ABC and PAP method, the SP method produced stronger staining intensity and ... More
Characterization of molecular interactions between intercellular adhesion molecule-1 and leukocyte function- associated antigen-1.
AuthorsWoska JR Jr, Morelock MM, Jeanfavre DD, Bormann BJ
JournalJ Immunol
PubMed ID8648112
The ability of soluble ICAM-1 (sICAM-1) to inhibit ICAM-1/LFA-1 adhesion events has been reported previously by numerous investigators. sICAM-1 has been demonstrated to inhibit various in vitro assays at concentrations ranging from 2 nM to greater than 40 microM. Given the hypothesis that circulating ICAM-1 modulates immune functions, the ability ... More
CD8Tc1 and Tc2 cells secrete distinct cytokine patterns in vitro and in vivo but induce similar inflammatory reactions.
AuthorsLi L, Sad S, Kägi D, Mosmann TR
JournalJ Immunol
PubMed ID9126975
Naive CD8 T cells, similar to CD4 T cells, can differentiate into at least two subsets of cytolytic effector cells with distinct cytokine patterns: T cytotoxic-1 (Tc1) cells secrete a Th1-like cytokine pattern, including IL-2 and IFN-gamma; and Tc2 cells produce Th2 cytokines, including IL-4, IL-5, and IL-10. As CD4 ... More