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Invitrogen
PP1 alpha Monoclonal Antibody (10C6-3)
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FIGURE: 1 / 13
PP1 alpha Antibody (43-8100) in ICC/IF
Immunofluorescence analysis of PP1 was performed using 70% confluent log phase MCF-7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with PP1 (10C6-3) Mouse Monoclonal Antibody (Product # 43-8100) at 2µg/mL in 0.1% BSA and incubated for 3 hours at room tem... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
43-8100
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
10C6-3
Immunogen
Mixture of two peptides from the C-terminal regions of human PP1 alpha protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum. The protein shows sequence similarity to the protein disulfide isomerase family. However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase. The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GADD34; MGC15877; MGC1674; PP-1A; protein phosphatase 1, catalytic subunit, alpha isozyme; protein phosphatase I alpha subunit (PPPIA) (EC 3.1.3.16); Protein phosphatase type 1 alpha, catalytic subunit; protein phosphatase-1d; serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit; testicular tissue protein Li 155; unnamed protein product
Gene Aliases: dism2; PP-1A; PP1A; PP1alpha; PPP1A; Ppp1c
UniProt ID: (Human) P62136, (Rat) P62138, (Mouse) P62137
Entrez Gene ID: (Human) 5499, (Dog) 403609, (Rat) 24668, (Mouse) 19045
phosphoprotein phosphatase activity
protein serine/threonine phosphatase activity
iron ion binding
protein binding
protein phosphatase 1 binding
hydrolase activity
phosphatase activity
ribonucleoprotein complex binding
macromolecular complex binding
transition metal ion binding
cadherin binding involved in cell-cell adhesion
RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
metal ion binding
protein phosphatase
promoter clearance from RNA polymerase II promoter
regulation of glycogen biosynthetic process
regulation of glycogen catabolic process
protein dephosphorylation
response to lead ion
circadian regulation of gene expression
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of transcription elongation from RNA polymerase II promoter
regulation of circadian rhythm
entrainment of circadian clock by photoperiod
telomere maintenance in response to DNA damage
regulation of translational initiation in response to stress
positive regulation of glycogen biosynthetic process
positive regulation of Ras protein signal transduction
protein stabilization
regulation of canonical Wnt signaling pathway
cell-cell adhesion
positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled
glycogen metabolic process
cell cycle
cell division
lung development
branching morphogenesis of an epithelial tube
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
telomere maintenance
transcription from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
regulation of translation
negative regulation of triglyceride catabolic process
double-strand break repair via alternative nonhomologous end joining
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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