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Invitrogen

Phospho-FOXO1/FOXO3 (Ser207, Ser212) Polyclonal Antibody

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View all (2) FOXO1/FOXO3 antibodies

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Phospho-FOXO1/FOXO3 (Ser207, Ser212) Polyclonal Antibody

Product Details

44-1230G

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 3 publications 3 publications
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human FOXO3 that contains serine 207.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533591

Target Information

a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AF6q21 protein; AFX; AFX1; forkhead box O1a; forkhead box O3A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO3A-; FOXO4; MGC120490; MLLT7; unnamed protein product

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Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; FKHRL1; FKHRL1P2; FOXO1; FOXO1A; FOXO2; FOXO3; FOXO3A

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UniProt ID: (Human) Q12778, (Human) O43524, (Mouse) Q9R1E0, (Mouse) Q9WVH4

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Entrez Gene ID: (Human) 2308, (Human) 2309, (Mouse) 56458, (Mouse) 56484

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding beta-catenin binding chromatin DNA binding ubiquitin protein ligase binding sequence-specific DNA binding protein phosphatase 2A binding promoter-specific chromatin binding transcription regulatory region sequence-specific DNA binding transcription cofactor binding protein kinase binding mitochondrial RNA polymerase binding promoter specificity activity sequence-specific double-stranded DNA binding transcription factor activity, transcription factor binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor binding core promoter binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation apoptotic process anatomical structure morphogenesis cell differentiation DNA damage response, signal transduction by p53 class mediator cellular response to oxidative stress glucose homeostasis positive regulation of neuron apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process blood vessel development autophagy cellular response to DNA damage stimulus insulin receptor signaling pathway cellular response to starvation positive regulation of autophagy cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process cellular response to hyperoxia cellular response to nitric oxide regulation of nucleic acid-templated transcription temperature homeostasis cellular glucose homeostasis gluconeogenesis regulation of gluconeogenesis protein acetylation gene expression response to insulin positive regulation of smooth muscle cell apoptotic process fat cell differentiation negative regulation of transcription, DNA-templated negative regulation of insulin secretion canonical Wnt signaling pathway regulation of transcription initiation from RNA polymerase II promoter cellular response to cold response to fatty acid energy homeostasis negative regulation of cardiac muscle hypertrophy in response to stress transcription from mitochondrial promoter response to xenobiotic stimulus positive regulation of muscle atrophy negative regulation of cell migration response to nutrient levels tumor necrosis factor-mediated signaling pathway cellular response to glucose starvation response to starvation positive regulation of regulatory T cell differentiation negative regulation of neuron differentiation brain morphogenesis cellular response to glucose stimulus cellular response to corticosterone stimulus cellular response to hypoxia response to dexamethasone positive regulation of hydrogen peroxide-mediated programmed cell death positive regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of reactive oxygen species biosynthetic process cellular response to beta-amyloid cellular response to nerve growth factor stimulus response to water-immersion restraint stress positive regulation of endothelial cell apoptotic process
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