Phospho-beta-Catenin pTyr654 + gamma-Catenin pTyr643 Antibody (1 B11)

Catalog number: 44212M

Invitrogen™  Related applications: Protein Assays and Analysis

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Description

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Reactivity: Human, Mouse
Validated Application: Western Blot
Host Species: Mouse
Clonality: Monoclonal
Clone ID: 1 B11
Target Gene: Catenin beta-Gamma [pY654/pY643]
Label or Dye: Unconjugated
Target Modification State: Phospho
Product Size: 50 µL
Shipping Condition: Dry Ice

Contents & storage

Store in freezer (-5 to -30°C).

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