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NeoBiotechnologies
NKX3.1 (Metastatic Prostate Adenocarcinoma Marker) Monoclonal Antibody (rNKX3.1/6620)
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FIGURE: 1 / 3
NKX3.1 (Metastatic Prostate Adenocarcinoma Marker) Antibody (4824-MSM19-P1ABX) in IHC (P)
IHC analysis of Formalin-fixed, paraffin-embedded human brain. Negative tissue control using rNKX3.1/6620 at 2 µg/mL in PBS for 30 min RT. HIER: Tris/EDTA, pH9.0, 45 min. 2 °: HRP-polymer, 30 min. DAB, 5 min.
Product Details
4824-MSM19-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
rNKX3.1/6620
Immunogen
Recombinant fragment (around aa 92-224) of human NKX3.1 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Homeobox protein NK-3 homolog A; Homeobox protein Nkx-3.1; NK homeobox, family 3, A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3-1 antibody; prostate-specific ag
Gene Aliases: BAPX2; NKX3; NKX3-1; NKX3.1; NKX3A
UniProt ID: (Human) Q99801
Entrez Gene ID: (Human) 4824
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
cysteine-type endopeptidase activator activity involved in apoptotic process
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
MADS box domain binding
DNA-binding transcription factor binding
transcription regulator inhibitor activity
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
urogenital system development
metanephros development
somitogenesis
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
cellular response to DNA damage stimulus
salivary gland development
heart development
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
regulation of signal transduction
positive regulation of gene expression
negative regulation of gene expression
cell differentiation
androgen receptor signaling pathway
prostate gland development
regulation of protein localization
response to testosterone
response to lipid
dorsal aorta development
regulation of cell proliferation
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
branching morphogenesis of an epithelial tube
epithelial cell proliferation
negative regulation of epithelial cell proliferation
regulation of multicellular organismal process
positive regulation of cell division
positive regulation of protein kinase B signaling
pharyngeal system development
branching involved in prostate gland morphogenesis
epithelial cell proliferation involved in salivary gland morphogenesis
epithelial cell proliferation involved in prostate gland development
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to steroid hormone stimulus
cellular response to hypoxia
cellular response to xenobiotic stimulus
positive regulation of androgen secretion
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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