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NeoBiotechnologies
NOX4/NADPH Oxidase 4 Monoclonal Antibody (NOX4, 1245)
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Product Details
50507-MSM1-P1ABX
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Class
Monoclonal
Type
Antibody
Clone
NOX4, 1245
Immunogen
Recombinant human NOX4 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Antibody is tested in direct ELISA.
Target Information
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; KOX1; NADPH oxidase 4; NOX 4; NOX-4; NOX4; NOX4v; Renal NAD(P)H-oxidase; unnamed protein product
Gene Aliases: KOX; KOX-1; NOX4; RENOX
UniProt ID: (Human) Q9NPH5
Entrez Gene ID: (Human) 50507
nucleotide binding
protein binding
electron carrier activity
NAD(P)H oxidase activity
superoxide-generating NADPH oxidase activity
oxidoreductase activity
oxygen sensor activity
heme binding
flavin adenine dinucleotide binding
modified amino acid binding
superoxide-generating NADPH oxidase activity
protein tyrosine kinase binding
cell morphogenesis
heart process
superoxide metabolic process
defense response
inflammatory response
negative regulation of cell proliferation
gene expression
intracellular signal transduction
superoxide anion generation
bone resorption
homocysteine metabolic process
positive regulation of protein kinase B signaling
cardiac muscle cell differentiation
positive regulation of ERK1 and ERK2 cascade
cellular response to glucose stimulus
reactive oxygen species metabolic process
reactive oxygen species biosynthetic process
positive regulation of DNA biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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