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NeoBiotechnologies
LEF1/TCF1 alpha (Transcription Factor) Recombinant Mouse Monoclonal Antibody (rLEF1/8854)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
51176-MSM9-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
rLEF1/8854
Immunogen
Recombinant fragment (around aa1-399) of human LEF1 protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:Human tonsil and thymus.
Cellular Location: Nucleus.
Target Information
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp586H0919; FLJ46390; HGNC:6551; hLEF-1 isoform; hLEF-1(8A); HMG Binding Domain; HMG box transcription factor; OTTHUMP00000219736; OTTHUMP00000219737; T cell-specific transcription factor 1-alpha; TCF1-alpha; unnamed protein product
Gene Aliases: ECTD1; ECTD17; LEF-1; TCF10; TCF1ALPHA; TCF7L3
UniProt ID: (Human) Q9UJU2
Entrez Gene ID: (Human) 51176
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
DNA binding, bending
estrogen receptor binding
histone deacetylase binding
sequence-specific DNA binding
gamma-catenin binding
armadillo repeat domain binding
C2H2 zinc finger domain binding
transcription regulator inhibitor activity
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
osteoblast differentiation
epithelial to mesenchymal transition
regulation of transcription from RNA polymerase II promoter
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
Wnt signaling pathway
cell differentiation
neutrophil differentiation
positive regulation of cell migration
positive regulation of granulocyte differentiation
negative regulation of interleukin-13 production
negative regulation of interleukin-4 production
negative regulation of interleukin-5 production
negative regulation of apoptotic process
negative regulation of DNA binding
positive regulation by host of viral transcription
T-helper 1 cell differentiation
positive regulation of gamma-delta T cell differentiation
positive regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of neurogenesis
canonical Wnt signaling pathway
cell chemotaxis
secondary palate development
protein localization to chromatin
cellular response to cytokine stimulus
cellular response to interleukin-4
positive regulation of cell proliferation in bone marrow
negative regulation of apoptotic process in bone marrow
positive regulation of cell cycle process
positive regulation of odontoblast differentiation
positive regulation of endothelial cell-matrix adhesion via fibronectin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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