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NeoBiotechnologies
Protein Tyrosine Phosphatase, non-receptor type 6 Monoclonal Antibody (PTPN6/7543)
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Product Details
5777-MSM3-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
PTPN6/7543
Immunogen
Recombinant fragment (around aa395-595) of human PTPN6 protein.
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: Human tonsil lymph node or spleen.
Cellular Location: Cytoplasm. Nucleus. In neurons; translocates into the nucleus after treatment with angiotensin II.
Target Information
SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.1.3.48; hematopoietic cell phosphatase; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; PTP-1C; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6; unnamed protein product
Gene Aliases: HCP; HCPH; HPTP1C; PTP-1C; PTP1C; PTPN6; SH-PTP1; SHP-1; SHP-1L; SHP1
UniProt ID: (Human) P29350
Entrez Gene ID: (Human) 5777
phosphotyrosine binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
protein binding
hydrolase activity
SH3 domain binding
protein kinase binding
SH2 domain binding
cell adhesion molecule binding
phosphorylation-dependent protein binding
MAPK cascade
mitotic cell cycle
pattern recognition receptor signaling pathway
hematopoietic progenitor cell differentiation
neutrophil activation involved in immune response
cytoplasmic pattern recognition receptor signaling pathway
negative regulation of humoral immune response mediated by circulating immunoglobulin
protein dephosphorylation
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
negative regulation of cell proliferation
negative regulation of angiogenesis
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
cell differentiation
platelet formation
T cell costimulation
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of mast cell activation involved in immune response
positive regulation of cell adhesion mediated by integrin
peptidyl-tyrosine dephosphorylation
intracellular signal transduction
megakaryocyte development
T cell proliferation
T cell activation
negative regulation of T cell proliferation
natural killer cell mediated cytotoxicity
regulation of apoptotic process
negative regulation of MAPK cascade
regulation of B cell differentiation
positive regulation of angiogenesis
negative regulation of innate immune response
T cell receptor signaling pathway
B cell receptor signaling pathway
negative regulation of B cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
regulation of release of sequestered calcium ion into cytosol
positive regulation of protein kinase B signaling
regulation of type I interferon-mediated signaling pathway
regulation of ERK1 and ERK2 cascade
platelet aggregation
inflammatory response to wounding
negative regulation of inflammatory response to wounding
CD27 signaling pathway
positive regulation of cytokine production involved in inflammatory response
negative regulation of neutrophil activation
epididymis development
regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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