SIRT1 Monoclonal Antibody (7F6G6)

RNA polymerase II core promoter proximal region sequence-specific DNA binding p53 binding transcription coactivator activity transcription corepressor activity NAD+ ADP-ribosyltransferase activity histone deacetylase activity enzyme inhibitor activity protein binding enzyme activator activity transferase activity ligand-dependent nuclear receptor binding NAD-dependent histone deacetylase activity deacetylase activity enzyme binding protein domain specific binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity NAD-dependent protein deacetylase activity histone binding identical protein binding HLH domain binding bHLH transcription factor binding metal ion binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) mitogen-activated protein kinase binding NAD+ binding NAD-dependent protein-lysine depropionylase activity DNA-binding transcription factor binding transcription regulator inhibitor activity histone H4K12 deacetylase activity, hydrolytic mechanism histone H3K deacetylase activity NAD-dependent protein lysine delactylase activity NAD-dependent protein decrotonylase activity NAD-dependent histone decrotonylase activity keratin filament binding protein ADP-ribosylase activity promoter-specific chromatin binding

single strand break repair negative regulation of transcription from RNA polymerase II promoter chromatin silencing at rDNA pyrimidine dimer repair by nucleotide-excision repair DNA synthesis involved in DNA repair angiogenesis ovulation from ovarian follicle cellular glucose homeostasis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation positive regulation of adaptive immune response gluconeogenesis chromatin organization methylation-dependent chromatin silencing protein deacetylation triglyceride mobilization apoptotic process cellular response to DNA damage stimulus response to oxidative stress transforming growth factor beta receptor signaling pathway spermatogenesis regulation of mitotic cell cycle muscle organ development circadian rhythm positive regulation of cell proliferation intrinsic apoptotic signaling pathway in response to DNA damage cellular response to starvation negative regulation of gene expression regulation of centrosome duplication negative regulation of triglyceride biosynthetic process positive regulation of cholesterol efflux regulation of lipid storage regulation of glucose metabolic process positive regulation of macroautophagy protein ubiquitination peptidyl-lysine acetylation triglyceride biosynthetic process cell differentiation macrophage differentiation negative regulation of transforming growth factor beta receptor signaling pathway endoplasmic reticulum unfolded protein response negative regulation of prostaglandin biosynthetic process heterochromatin assembly telomeric heterochromatin assembly protein destabilization negative regulation of TOR signaling regulation of endodeoxyribonuclease activity negative regulation of NF-kappaB transcription factor activity positive regulation of proteasomal ubiquitin-dependent protein catabolic process response to insulin circadian regulation of gene expression leptin-mediated signaling pathway regulation of smooth muscle cell apoptotic process hippo signaling negative regulation of hippo signaling cellular triglyceride homeostasis regulation of peroxisome proliferator activated receptor signaling pathway regulation of cell proliferation cellular response to glucose starvation negative regulation of phosphorylation response to hydrogen peroxide behavioral response to starvation cholesterol homeostasis intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of apoptotic process positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of neuron apoptotic process positive regulation of blood vessel endothelial cell migration response to leptin positive regulation of MHC class II biosynthetic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of DNA repair positive regulation of angiogenesis negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of transcription by glucose positive regulation of insulin receptor signaling pathway regulation of lipid biosynthetic process rhythmic process regulation of developmental process white fat cell differentiation positive regulation of smooth muscle cell differentiation regulation of multicellular organismal process attachment of mitotic spindle microtubules to kinetochore maintenance of nucleus location positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling fatty acid homeostasis negative regulation of androgen receptor signaling pathway positive regulation of macrophage cytokine production positive regulation of small molecule metabolic process cellular response to hydrogen peroxide regulation of bile acid biosynthetic process UV-damage excision repair cellular response to tumor necrosis factor cellular response to hypoxia cellular response to ionizing radiation signal transduction by p53 class mediator tricarboxylic acid metabolic process regulation of brown fat cell differentiation stress-induced premature senescence energy homeostasis protein depropionylation DNA repair-dependent chromatin remodeling regulation of cellular response to heat negative regulation of signal transduction by p53 class mediator negative regulation of protein acetylation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of adipose tissue development cellular response to leukemia inhibitory factor positive regulation of macrophage apoptotic process positive regulation of cAMP-dependent protein kinase activity negative regulation of cellular response to testosterone stimulus negative regulation of peptidyl-lysine acetylation negative regulation of cellular senescence positive regulation of cellular senescence positive regulation of double-strand break repair