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NeoBiotechnologies
BMI1 Monoclonal Antibody (BMI1, 2689)
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Product Details
648-MSM1-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
BMI1, 2689
Immunogen
Recombinant fragment of human BMI1 protein (around aa 142-326)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B lymphoma Mo-MLV insertion region 1 homolog; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; COMMD3; murine leukemia viral (bmi-1) oncogene homolog; Pcgf4 antibody; Polycomb complex protein BMI-1; polycomb group protein Bmi1; Polycomb group RING finger protein 4; putative; RING finger protein 51; RP11-573G6.1
Gene Aliases: BMI1; flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
UniProt ID: (Human) P35226
Entrez Gene ID: (Human) 648
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
in utero embryonic development
chromatin organization
chromatin remodeling
methylation-dependent chromatin silencing
humoral immune response
segment specification
brain development
regulation of gene expression
rostrocaudal neural tube patterning
hemopoiesis
positive regulation of B cell proliferation
positive regulation of immature T cell proliferation in thymus
negative regulation of gene expression, epigenetic
somatic stem cell division
positive regulation of fibroblast proliferation
embryonic skeletal system morphogenesis
embryonic skeletal system development
positive regulation of ubiquitin-protein transferase activity
cellular response to interleukin-1
cellular response to dexamethasone stimulus
regulation of kidney development
apoptotic signaling pathway
regulation of adaxial/abaxial pattern formation
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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