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RBPJ Monoclonal Antibody (2F12G12)

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RBPJ Monoclonal Antibody (2F12G12)

Product Details

66132-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2F12G12

Immunogen

RBPJ Fusion Protein Ag6302 (138-486 aa encoded by BC064976)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.45 mg/mL

Amount

67.5 µg

Purification

Protein G

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DIGVFLSKR IKVISKPSKK KQSLKNADLC IASGTKVALF NRLRSQTVST RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG YIHYGQTVKL VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP VTPVPVVESL QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES MLCVVPDISA FREGWRWVRQ PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP RPHCSAAGAI LRANSSQVPP NESNTNSEGS YTNASTNSTS VTSSTATVVS (138-486 aa encoded by BC064976)

Target Information

CSL plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The protein is abundantly expressed in heart and skeletal muscle and expression is increased by passive stretch. Mutations in this gene can lead to X-linked deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CBF-1; CSL family DNA binding factor 1; H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; J kappa-recombination signal-binding protein; RBP-J; RBP-J kappa; rbp-jkappa; Recombining binding protein suppressor of hairless; Renal carcinoma antigen NY-REN-30; suppressor of hairless homolog; unnamed protein product

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Gene Aliases: AOS3; CBF-1; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBP-J kappa; RBP-JK; RBPJ; RBPJK; RBPSUH; SUH

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UniProt ID: (Human) Q06330

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Entrez Gene ID: (Human) 3516

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis somitogenesis epithelial to mesenchymal transition blood vessel remodeling inflammatory response to antigenic stimulus secondary heart field specification outflow tract morphogenesis endocardium development endocardium morphogenesis aortic valve development pulmonary valve development epithelial to mesenchymal transition involved in endocardial cushion formation cardiac left ventricle morphogenesis ventricular trabecula myocardium morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter humoral immune response Notch signaling pathway positive regulation of transcription of Notch receptor target heart development cell proliferation auditory receptor cell fate commitment epidermal cell fate specification regulation of gene expression positive regulation of gene expression pituitary gland development hemopoiesis cell differentiation neuron differentiation B cell differentiation keratinocyte differentiation negative regulation of ossification positive regulation of BMP signaling pathway somatic stem cell population maintenance dorsal aorta morphogenesis atrioventricular canal development defense response to bacterium myeloid dendritic cell differentiation regulation of generation of precursor metabolites and energy cell fate commitment negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation animal organ development sebaceous gland development hair follicle maturation artery morphogenesis epithelial cell proliferation regulation of epithelial cell proliferation positive regulation of epithelial cell proliferation positive regulation of cardiac muscle cell proliferation cardiac muscle cell myoblast differentiation ventricular septum morphogenesis Clara cell differentiation labyrinthine layer blood vessel development arterial endothelial cell fate commitment regulation of cell adhesion involved in heart morphogenesis stem cell proliferation blood vessel lumenization positive regulation of canonical Wnt signaling pathway blood vessel endothelial cell fate specification negative regulation of cold-induced thermogenesis positive regulation of ERBB signaling pathway positive regulation of ephrin receptor signaling pathway positive regulation of cell proliferation involved in heart morphogenesis negative regulation of stem cell proliferation
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