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Proteintech
IL-4 Monoclonal Antibody (1G2C5)
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Product Details
66142-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Pig
Published species
Human,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1G2C5
Immunogen
IL-4 Fusion Protein Ag9940 (24-153 aa encoded by BC070123)
Conjugate
Form
Liquid
Concentration
0.74 mg/mL
Amount
111 µg
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GHKCDITLQ EIIKTLNSLT EQKTLCTELT VTDIFAASKN TTEKETFCRA ATVLRQFYSH HEKDTRCLGA TAQQFHRHKQ LIRFLKRLDR NLWGLAGLNS CPVKEANQST LENFLERLKT IMREKYSKCS S (24-153 aa encoded by BC070123)
Target Information
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B cell growth factor 1; B-cell stimulatory factor 1; B_cell stimulatory factor 1; Binetrakin; BSF-1; cytokine; H-IL-4; IL-4; IL-4v2; IL4; ILN; Interleukin; interleukin 4; Interleukin-4; Interleukin4; Lymphocyte stimulatory factor 1; M-IL-4; MGC79402; Pitrakinra
Gene Aliases: BCGF-1; BCGF1; BSF-1; BSF1; IL-4; IL4
UniProt ID: (Human) P05112, (Pig) Q04745
Entrez Gene ID: (Human) 3565, (Pig) 397225
negative regulation of transcription from RNA polymerase II promoter
immune response
JAK-STAT cascade
cholesterol metabolic process
positive regulation of cell proliferation
positive regulation of gene expression
negative regulation of epithelial cell migration
positive regulation of macroautophagy
B cell differentiation
positive regulation of cell migration
positive regulation of B cell proliferation
negative regulation of tumor necrosis factor production
positive regulation of interleukin-10 production
positive regulation of interleukin-13 production
interleukin-4-mediated signaling pathway
type 2 immune response
positive regulation of T cell proliferation
T cell activation
B cell activation
macrophage activation
myeloid dendritic cell differentiation
negative regulation of apoptotic process
regulation of isotype switching
leukocyte activation
positive regulation of MHC class II biosynthetic process
positive regulation of T cell differentiation
negative regulation of osteoclast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of receptor-mediated endocytosis
positive regulation of isotype switching to IgE isotypes
positive regulation of isotype switching to IgG isotypes
negative regulation of inflammatory response
regulation of immune response
regulation of multicellular organismal process
regulation of primary metabolic process
dendritic cell differentiation
positive regulation of cold-induced thermogenesis
neuroinflammatory response
negative regulation of neuroinflammatory response
positive regulation of beta-amyloid clearance
positive regulation of cellular respiration
negative regulation of complement-dependent cytotoxicity
negative regulation of cellular response to transforming growth factor beta stimulus
negative regulation of endothelial cell apoptotic process
positive regulation of T-helper 2 cell cytokine production
positive regulation of ATP biosynthetic process
positive regulation of protein phosphorylation
positive regulation of JAK-STAT cascade
regulation of protein export from nucleus
positive regulation of establishment of endothelial barrier
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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