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Proteintech
OTUD7B Monoclonal Antibody (2C12D9)
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Product Details
66276-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
2C12D9
Immunogen
OTUD7B Fusion Protein Ag10513 (1-355 aa encoded by BC020622)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTLDMDAVL SDFVRSTGAE PGLARDLLEG KNWDVNAALS DFEQLRQVHA GNLPPSFSEG SGGSRTPEKG FSDREPTRPP RPILQRQDDI VQEKRLSRGI SHASSSIVSL ARSHVSSNGG GGGSNEHPLE MPICAFQLPD LTVYNEDFRS FIERDLIEQS MLVALEQAGR LNWWVSVDPT SQRLLPLATT GDGNCLLHAA SLGMWGFHDR DLMLRKALYA LMEKGVEKEA LKRRWRWQQT QQNEESGLVY TEDEWQKEWN ELIKLASSEP RMHLGTNGAN CGGVESSEEP VYESLEEFHV FVLAHVLRRP IVVVADTMLR DSGGEAFAPI PFGGIYLPLE VPASQCHRSP LVLAYD (1-355 aa encoded by B C020622)
Target Information
Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2. Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cellular zinc finger anti-NF-kappa-B protein; cellular zinc finger anti-NF-kappaB Cezanne; Cezanne; OTU domain containing 7B; OTU domain-containing protein 7B; unnamed protein product; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne; zinc finger, A20 domain containing 1
Gene Aliases: CEZANNE; OTUD7B; ZA20D1
UniProt ID: (Human) Q6GQQ9
Entrez Gene ID: (Human) 56957
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
adaptive immune response
immune system process
mucosal immune response
proteolysis
protein deubiquitination
negative regulation of interleukin-8 production
protein K11-linked deubiquitination
TORC1 signaling
TORC2 signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
protein K63-linked deubiquitination
protein K48-linked deubiquitination
protein deubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of protein localization to nucleus
negative regulation of TORC1 signaling
positive regulation of TORC2 signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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