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Proteintech
VPS37A Monoclonal Antibody (1F9A4)
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Product Details
66327-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1F9A4
Immunogen
VPS37A Fusion Protein Ag19108 (1-174 aa encoded by BC022363)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MPDVPDAFP ELSELSVSQL TDMNEQEEVL LEQFLTLPQL KQIITDKDDL VKSIEELARK NLLLEPSLEA KRQTVLDKYE LLTQMKSTFE KKMQRQHELS ESCSASALQA RLKVAAHEAE EESDNIAEDF LEGKMEIDDF LSSFMEKRTI CHCRRAKEEK LQQAIAMHSQ FHAPL (1-174 aa encoded by BC022363)
Target Information
This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ESCRT-I complex subunit VPS37A; Hepatocellular carcinoma-related protein 1; hVps37A; polyglutamine binding protein 2; unnamed protein product; vacuolar protein sorting 37 homolog A; Vacuolar protein sorting-associated protein 37A; VPS37A, ESCRT-I subunit
Gene Aliases: HCRP1; PQBP2; SPG53; VPS37A
UniProt ID: (Human) Q8NEZ2
Entrez Gene ID: (Human) 137492
protein targeting to membrane
protein targeting to vacuole
protein transport
macroautophagy
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
membrane fission
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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