Search

  • Contact Us
  • Quick Order

Proteintech

FOS Monoclonal Antibody (1G2C5)

53 References
View all (77) c-Fos antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
FOS Monoclonal Antibody (1G2C5)

Product Details

66590-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:10,000
View 42 publications 42 publications

Immunohistochemistry (IHC)

-
View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000
-

Immunocytochemistry (ICC/IF)

-
View 6 publications 6 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1G2C5

Immunogen

FOS Fusion Protein Ag24340 (196-341 aa encoded by BC004490)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ILAAHRPAC KIPDDLGFPE EMSVASLDLT GGLPEVATPE SEEAFTLPLL NDPEPKPSVE PVKSISSMEL KTEPFDDFLF PASSRPSGSE TARSVPDMDL SGSFYAADWE PLHSGSLGMG PMATELEPLC TPVVTCTPSC TAYTSSF (196-341 aa encoded by BC004490 )

Target Information

FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: activator protein 1; c-fos oncogene; cellular oncogene c-fos; Cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FBJ osteosarcoma oncogene; FOS; Fos proto-oncogene, AP-1 trancription factor subunit; Fos proto-oncogene, AP-1 transcription factor subunit; G0/G1 switch regulatory protein 7; Protein c-Fos; Proto-oncogene c-Fos; proto-oncogene cFOS; proto-oncogene protein c-fos; Transcription factor AP-1 subunit c-Fos; unnamed protein product; v-fos FBJ murine osteosarcoma viral oncogene homolog

View more View less

Gene Aliases: AP-1; C-FOS; cFos; D12Rfj1; FOS; G0S7; p55

View more View less

UniProt ID: (Human) P01100, (Mouse) P01101, (Rat) P12841

View more View less

Entrez Gene ID: (Human) 2353, (Mouse) 14281, (Rat) 314322

View more View less

Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding macromolecular complex binding RNA polymerase II sequence-specific DNA binding transcription factor binding R-SMAD binding sequence-specific double-stranded DNA binding promoter-specific chromatin binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor binding transcription regulatory region DNA binding protein heterodimerization activity basic leucine zipper transcription factor
Process(es)
conditioned taste aversion neural retina development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response transforming growth factor beta receptor signaling pathway nervous system development female pregnancy response to xenobiotic stimulus response to light stimulus response to mechanical stimulus response to gravity response to toxic substance regulation of gene expression response to activity skeletal muscle cell proliferation cerebral cortex development neuron differentiation osteoclast differentiation response to lipopolysaccharide response to progesterone response to insulin cellular response to hormone stimulus response to cytokine cellular response to zinc ion starvation cellular response to reactive oxygen species response to immobilization stress skeletal muscle cell differentiation response to muscle stretch response to ethanol positive regulation of osteoclast differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to steroid hormone response to corticosterone myoblast proliferation response to cAMP SMAD protein signal transduction cellular response to calcium ion cellular response to tumor necrosis factor cellular response to epidermal growth factor stimulus cellular response to parathyroid hormone stimulus cellular response to hypoxia cellular response to transforming growth factor beta stimulus medium-term memory integrated stress response signaling positive regulation of pri-miRNA transcription from RNA polymerase II promoter mononuclear cell differentiation response to forskolin cellular response to phorbol 13-acetate 12-myristate cellular response to prolactin cellular response to extracellular stimulus response to drug aging response to cold response to organic cyclic compound sleep
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support