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Proteintech
HSPB1 Monoclonal Antibody (3E7A1)
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Product Details
66767-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3E7A1
Immunogen
HSPB1 Fusion Protein Ag27859 (1-205 aa encoded by BC012768)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTERRVPFS LLRGPSWDPF RDWYPHSRLF DQAFGLPRLP EEWSQWLGGS SWPGYVRPLP PAAIESPAVA APAYSRALSR QLSSGVSEIR HTADRWRVSL DVNHFAPDEL TVKTKDGVVE ITGKHEERQD EHGYISRCFT RKYTLPPGVD PTQVSSSLSP EGTLTVEAPM PKLATQSNEI TIPVTFESRA QLGGPEAAKS DETAAK (1-205 aa encoded by B C012768)
Target Information
In response to adverse changes in their environment, cells from many organisms increase the expression of a class of proteins referred to as heat shock or stress proteins. HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein which functions as a molecular chaperone that maintains denatured proteins in a folding-competent state. It plays a role in stress resistance and actin organization. Through its molecular chaperone activity, HSP27 regulates numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and Neuronopathy distal hereditary motor 2B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 27-kda heat shock protein; 28 kDa heat shock protein; DKFZp586P1322; epididymis secretory protein Li 102; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; heat shock 27kD protein 1; heat shock 27kDa protein 1; Heat shock protein; Heat shock protein beta-1; Heat shock protein family B member 1; HS; HSP; HSP 27; HSP27; HSPB1; Phospho-HSP 27; SRP27; Stress-responsive protein 27; unnamed protein product
Gene Aliases: CMT2F; HEL-S-102; HMN2B; HMND3; HS.76067; Hsp25; HSP27; HSP28; HSPB1; SRP27
UniProt ID: (Human) P04792
Entrez Gene ID: (Human) 3315
RNA binding
protein kinase C binding
protein binding
protein kinase C inhibitor activity
protein kinase binding
identical protein binding
protein homodimerization activity
ubiquitin binding
protein binding involved in protein folding
unfolded protein binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
regulation of protein phosphorylation
regulation of translational initiation
protein folding
response to unfolded protein
response to heat
response to virus
regulation of autophagy
positive regulation of interleukin-1 beta production
positive regulation of tumor necrosis factor production
intracellular signal transduction
cellular response to vascular endothelial growth factor stimulus
protein refolding
negative regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
vascular endothelial growth factor receptor signaling pathway
platelet aggregation
negative regulation of protein kinase C signaling
anterograde axonal protein transport
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
positive regulation of endothelial cell chemotaxis
negative regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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