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Invitrogen

Phospho-STAT1 (Tyr701) Recombinant Rabbit Monoclonal Antibody (15H13L67)

Advanced Verification
4 Published Figures
7 References
View all (84) STAT1 antibodies

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Phospho-STAT1 (Tyr701) Recombinant Rabbit Monoclonal Antibody (15H13L67)

Product Details

700349

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-2 µg/mL
View 4 publications 4 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100
-

Immunocytochemistry (ICC/IF)

0.5-2 µg/mL
View 2 publications 2 publications
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

15H13L67

Immunogen

A peptide corresponding to amino acids 697-706 of P42224.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532315

Product Specific Information

This antibody is predicted to react with orangutan, Macaque, bovine, porcine, ovine, elk, bat, Xenopus, mouse, rat, chicken and salmon based on sequence homology.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: DKFZp686B04100; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; Signal transducer and activator of transcription 1-alpha/beta; STAT; STAT 1; STAT-1; stat1 alpha; transcription factor; Transcription factor ISGF-3 components p91/p84; transcription factor; 91 kDa; unnamed protein product

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Gene Aliases: 2010005J02Rik; AA408197; CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT1; STAT91

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UniProt ID: (Human) P42224

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Entrez Gene ID: (Human) 6772, (Mouse) 20846

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcription coactivator binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding tumor necrosis factor receptor binding protein binding enzyme binding CCR5 chemokine receptor binding histone acetyltransferase binding histone binding identical protein binding protein homodimerization activity sequence-specific DNA binding ubiquitin-like protein ligase binding cadherin binding protein phosphatase 2A binding promoter-specific chromatin binding transcription factor activity, RNA polymerase II core promoter sequence-specific signal transducer activity DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of endothelial cell proliferation positive regulation of mesenchymal cell proliferation positive regulation of defense response to virus by host negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade response to nutrient blood circulation positive regulation of cell proliferation response to xenobiotic stimulus response to mechanical stimulus negative regulation of angiogenesis positive regulation of interferon-alpha production cellular response to insulin stimulus tumor necrosis factor-mediated signaling pathway response to cytokine response to interferon-gamma response to interferon-beta cellular response to interferon-beta interleukin-7-mediated signaling pathway interleukin-9-mediated signaling pathway regulation of cell proliferation response to hydrogen peroxide regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling response to peptide hormone endothelial cell migration positive regulation of nitric oxide biosynthetic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade negative regulation by virus of viral protein levels in host cell positive regulation of smooth muscle cell proliferation negative regulation of developmental process response to cAMP defense response to virus interferon-gamma-mediated signaling pathway type I interferon signaling pathway renal tubule development interleukin-27-mediated signaling pathway cellular response to cytokine stimulus cellular response to interferon-gamma metanephric mesenchymal cell proliferation involved in metanephros development metanephric mesenchymal cell differentiation negative regulation of metanephric nephron tubule epithelial cell differentiation receptor signaling pathway via STAT transcription, DNA-templated transcription from RNA polymerase II promoter activation of cysteine-type endopeptidase activity involved in apoptotic process response to bacterium cytokine-mediated signaling pathway lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide negative regulation of macrophage fusion response to drug response to exogenous dsRNA cellular response to lipopolysaccharide
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