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Invitrogen

STAT5 beta Recombinant Rabbit Monoclonal Antibody (13H20L4)

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STAT5 beta Recombinant Rabbit Monoclonal Antibody (13H20L4)

Product Details

701109

Applications
Tested Dilution
Publications

Western Blot (WB)

2-5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:50
-

Immunocytochemistry (ICC/IF)

2-4 µg
-

ChIP assay (ChIP)

3 µg
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

13H20L4

Immunogen

Peptide corresponding to amino acids 49-57 of human signal transducer and activator of transcription 5b (this region has no sequence homology with other STATs)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532392

Product Specific Information

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: mammary gland factor STAT5B; Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B

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Gene Aliases: GHISID2; STAT5; STAT5B

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UniProt ID: (Human) P51692, (Mouse) P42232

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Entrez Gene ID: (Human) 6777, (Mouse) 20851

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding glucocorticoid receptor binding identical protein binding protein homodimerization activity protein dimerization activity RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding double-stranded DNA binding signal transducer activity protein phosphatase binding sequence-specific DNA binding DNA-binding transcription factor
Process(es)
mitotic cell cycle luteinization natural killer cell differentiation natural killer cell proliferation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter defense response signal transduction JAK-STAT cascade sex differentiation female pregnancy lactation cell proliferation positive regulation of cell proliferation regulation of steroid metabolic process cytokine-mediated signaling pathway taurine metabolic process lipid storage lymphocyte differentiation regulation of cell adhesion B cell differentiation erythrocyte differentiation regulation of epithelial cell differentiation response to estradiol positive regulation of interleukin-2 production positive regulation of natural killer cell proliferation positive regulation of natural killer cell differentiation cellular response to hormone stimulus myeloid cell apoptotic process negative regulation of myeloid cell apoptotic process T cell differentiation in thymus erythropoietin-mediated signaling pathway regulation of multicellular organism growth positive regulation of multicellular organism growth positive regulation of activated T cell proliferation regulation of cell proliferation natural killer cell mediated cytotoxicity progesterone metabolic process gamma-delta T cell differentiation T cell homeostasis response to peptide hormone positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation positive regulation of lymphocyte differentiation negative regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development positive regulation of inflammatory response activated T cell proliferation JAK-STAT cascade involved in growth hormone signaling pathway response to interleukin-2 response to interleukin-4 response to interleukin-15 cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus mast cell migration regulation of hemopoiesis allantoin metabolic process liver development citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process transcription, DNA-templated isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process acute-phase response response to lipopolysaccharide prolactin signaling pathway negative regulation of apoptotic process positive regulation of interleukin-2 biosynthetic process creatinine metabolic process positive regulation of smooth muscle cell proliferation positive regulation of cellular component movement
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