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Invitrogen
IFN alpha Recombinant Rabbit Monoclonal Antibody (9H1L1)
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Product Details
701275
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
9H1L1
Immunogen
Recombinant protein corresponding to amino acids 24-189 of human Interferon alpha
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-2a interferon; cytokine; ifa; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN-alpha-1/13; IFN-alpha-2; IFNA2; IFNA2b; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; Interferon alpha 13 (IFNA13); interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; Interferon alpha leukocyte (IFL); interferon alpha-1/13; Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-2; Interferon alpha-A; interferon alpha-D; Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); interferon-alpha1; LeIF A; MGC138207; MGC138505; MGC138507; unnamed protein product
Gene Aliases: IFL; IFN; IFN-ALPHA; IFN-alpha-2; IFN-alphaA; IFN-alphaD; IFNA; IFNA13; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFNA@; leIF A; leIF D
UniProt ID: (Human) P01563
Entrez Gene ID: (Human) 3439, (Human) 3440
adaptive immune response
T cell activation involved in immune response
B cell activation involved in immune response
natural killer cell activation involved in immune response
defense response
humoral immune response
response to exogenous dsRNA
viral entry into host cell
defense response to virus
type I interferon signaling pathway
cellular response to virus
antiviral innate immune response
apoptotic process
inflammatory response
cell surface receptor signaling pathway
cell-cell signaling
negative regulation of gene expression
negative regulation of interleukin-13 production
negative regulation of interleukin-5 production
negative regulation of T cell differentiation
negative regulation of transcription, DNA-templated
negative regulation of viral entry into host cell
receptor signaling pathway via STAT
negative regulation of T-helper 2 cell cytokine production
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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