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Invitrogen
DLX2 Recombinant Rabbit Monoclonal Antibody (1H13L11)
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FIGURE: 1 / 4
DLX2 Antibody (702009) in ICC/IF
For immunofluorescence analysis, NTERA-2 cells were fixed and permeabilized for detection of endogenous DLX2 using Anti- DLX2 Recombinant Rabbit Monoclonal Antibody (Product # 702009, 5 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of DLX2 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S369... View More
Product Details
702009
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
1H13L11
Immunogen
Peptides corresponding to human DLX2 [1) aa127-aa141 2) aa311-aa328]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Bovine, Mouse
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DII A; distal-less homeo box 2; Homeobox protein DLX-2; Homeobox protein TES-1; unnamed protein product
Gene Aliases: AW121999; Dlx-2; DLX2; TES-1; TES1
UniProt ID: (Human) Q07687, (Mouse) P40764
Entrez Gene ID: (Human) 1746, (Mouse) 13392
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
single-stranded RNA binding
protein binding
sequence-specific double-stranded DNA binding
sequence-specific DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
Notch signaling pathway
brain development
proximal/distal pattern formation
neuroblast differentiation
subpallium development
hippocampus development
olfactory bulb development
forebrain neuron differentiation
cerebral cortex GABAergic interneuron differentiation
cerebral cortex GABAergic interneuron fate commitment
cell differentiation
odontogenesis of dentin-containing tooth
positive regulation of cell differentiation
negative regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of photoreceptor cell differentiation
embryonic cranial skeleton morphogenesis
embryonic skeletal system development
oligodendrocyte differentiation
negative regulation of oligodendrocyte differentiation
branching morphogenesis of a nerve
cartilage development
GABAergic neuron differentiation
positive regulation of amacrine cell differentiation
transcription from RNA polymerase II promoter
multicellular organism development
regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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