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Invitrogen
C17orf96 Recombinant Rabbit Monoclonal Antibody (5H7L8)
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FIGURE: 1 / 4
C17orf96 Antibody (703052) in ICC/IF
For immunofluorescence analysis, HEK-293 cells were fixed and permeabilized for detection of endogenous C17orf96 using Anti-C17orf96 Recombinant Rabbit Monoclonal Antibody (Product # 703052, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of C17orf96 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with ... View More
Product Details
703052
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
5H7L8
Immunogen
Peptides corresponding to human C17orf96 [aa130-aa148, aa360-aa379]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Cat, Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
Elongin BC and Polycomb repressive complex 2-associated protein (EPOP) also know as C17ORF96 is a scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex. It is required to fine tune the transcriptional status of polycomb group (PcG) target genes in embryonic stem cells (ESCs). C17ORF96 also plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression of PcG target genes. It acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. C17ORF96 also has interacts with USP7 and promotes deubiquitination of H2B at promoter sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Elongin BC and Polycomb repressive complex 2-associated protein; Embryonic stem cell-specific PRC2 subunit p48; ES cell-specific PRC2 subunit p48; proline rich 28; Proline-rich protein 28; uncharacterized protein C17orf96; uncharacterized protein C17orf96 homolog
Gene Aliases: AA409164; AI413509; AW539173; C17orf96; E13; EPOP; esPRC2p48; PRR28
UniProt ID: (Mouse) Q7TNS8, (Human) A6NHQ4
Entrez Gene ID: (Mouse) 103551, (Human) 100170841
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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