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Invitrogen
MAVS Recombinant Rabbit Monoclonal Antibody (20H41L5)
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FIGURE: 1 / 3
MAVS Antibody (703153) in WB
Western blot was performed using Anti-MAVS Recombinant Rabbit Monoclonal Antibody (Product # 703153) and a ~60 kDa band corresponding to MAVS was observed only in the Human cell lines tested. Membrane enriched extracts (30 µg lysate) of HeLa (Lane 1), THP-1 (Lane 2), A549 (Lane 3), Hep G2 (Lane 4) and NIH/3T3 (Lane 5) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was pro... View More
Product Details
703153
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Monoclonal
Type
Antibody
Clone
20H41L5
Immunogen
Protein corresponding to human MAVS [aa250-aa540]
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
This antibody is predicted to react with Monkey, Mouse, Rat, Bovine.
Target Information
Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. MAVS is a mitochondrial membrane protein that was identified as a critical component in the IFN beta signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. MAVS is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. MAVS also interacts with the IKK-alpha, IKK-beta and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. Multiple isoforms of MAVS are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; Cardif; IFN-B promoter stimulator 1; Interferon beta promoter stimulator protein 1; IPS-1; MAVS; Mitochondrial antiviral-signaling protein; Putative NF-kappa-B-activating protein 031N; unnamed protein product; virus-induced signaling adaptor; Virus-induced-signaling adapter; VISA; VISA1a; VISA1b
Gene Aliases: CARDIF; IPS-1; IPS1; KIAA1271; MAVS; VISA
UniProt ID: (Human) Q7Z434
Entrez Gene ID: (Human) 57506
activation of innate immune response
positive regulation of defense response to virus by host
immune system process
positive regulation of myeloid dendritic cell cytokine production
cytoplasmic pattern recognition receptor signaling pathway
signal transduction
mRNA transcription
positive regulation of type I interferon production
positive regulation of interferon-alpha production
positive regulation of interferon-beta production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
intracellular signal transduction
positive regulation of protein import into nucleus
defense response to bacterium
positive regulation of I-kappaB kinase/NF-kappaB signaling
NLRP3 inflammasome complex assembly
negative regulation of viral genome replication
innate immune response
positive regulation of transcription from RNA polymerase II promoter
defense response to virus
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
positive regulation of response to cytokine stimulus
protein localization to mitochondrion
cellular response to exogenous dsRNA
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of IP-10 production
antiviral innate immune response
regulation of peroxisome organization
positive regulation of NLRP3 inflammasome complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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