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NeoBiotechnologies
TGF-alpha (Transforming Growth Factor alpha) Monoclonal Antibody (TG86, P/T1)
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Product Details
7039-MSM5-P0
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rabbit,
Zebrafish
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
TG86, P/T1
Immunogen
A 10-amino acid synthetic peptide (aa34-43. PPVAAAVVSH) from human TGFalpha. (TG86 & P/T1)
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein L
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
TGF-alpha is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-alpha induces anchorage-independence transformation in cultured cells. Human, murine and rat TGF-alpha are cross-species reactive. TGFalpha (aa 50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protransforming growth factor alpha; TGF a; TGF α; TGF-alpha; TGFalpha; TGFα; Transforming growth factor; transforming growth factor-alpha precursor old gene name 'LU0044C'; unnamed protein product
Gene Aliases: si:ch211-10e8.7; TFGA; TGFA
UniProt ID: (Human) P01135
Entrez Gene ID: (Human) 7039, (Rabbit) 100009482, (Zebrafish) 100034402
angiogenesis
cell surface receptor signaling pathway
epidermal growth factor receptor signaling pathway
positive regulation of cell proliferation
intracellular signal transduction
ERBB2-EGFR signaling pathway
positive regulation of MAPK cascade
positive regulation of mitotic nuclear division
positive regulation of epithelial cell proliferation
positive regulation of cell division
mammary gland alveolus development
hepatocyte proliferation
activation of MAPK activity
positive regulation of epidermal growth factor-activated receptor activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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