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Invitrogen

CCL5 (RANTES) Recombinant Superclonal™ Antibody (25HCLC)

2 Published Figures
11 References
View all (29) CCL5 (RANTES) antibodies

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Product Details

710001

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
View 5 publications 5 publications

Immunohistochemistry (IHC)

-
View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

2 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Superclonal

Type

Antibody

Clone

25HCLC

Immunogen

proprietary

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.2-7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2532515

Product Specific Information

This antibody is predicted to react with rat and human based on sequence homology.

Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.

Target Information

CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: beta-chemokine RANTES; Ccl5; chemokine (C-C motif) ligand 5; eosinophil chemotactic cytokine; MGC17164; monocyte chemoattractant cytokine; OTTHUMP00000197106; RANTES; regulated upon activation normal T-cell expressed and secreted; regulated upon activation, normally T-expressed, and presumably secreted; SIS δ; SIS-delta; SISδ; small inducible cytokine subfamily A (Cys-Cys), member 5; small-inducible cytokine A5; T cell-specific protein precursor; T-cell specific protein p288; T-cell-specific protein RANTES; unnamed protein product

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Gene Aliases: D17S136E; eoCP; MuRantes; RANTES; SCYA5; SIS-delta; SISd; TCP228

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UniProt ID: (Human) P13501, (Mouse) P30882

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Entrez Gene ID: (Human) 6352, (Mouse) 20304, (Rat) 81780

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Function(s)
phosphatidylinositol phospholipase C activity protein kinase activity protein binding chemokine activity phospholipase activator activity receptor signaling protein tyrosine kinase activator activity CCR1 chemokine receptor binding CCR4 chemokine receptor binding CCR5 chemokine receptor binding chemoattractant activity chemokine receptor binding identical protein binding protein homodimerization activity chemokine receptor antagonist activity CCR chemokine receptor binding heparin binding
Process(es)
positive regulation of defense response to virus by host calcium ion transport cellular calcium ion homeostasis exocytosis inflammatory response immune response leukocyte cell-cell adhesion G-protein coupled receptor signaling pathway cell-cell signaling response to toxic substance positive regulation of gene expression positive regulation of macrophage chemotaxis positive regulation of T cell chemotaxis positive regulation of smooth muscle cell migration positive regulation of cell migration pseudopodium assembly phospholipase D-activating G-protein coupled receptor signaling pathway positive regulation of fever generation positive regulation of TOR signaling positive regulation of cell-cell adhesion mediated by integrin response to cytokine positive regulation of homotypic cell-cell adhesion response to interferon-gamma response to tumor necrosis factor T-helper 1 cell diapedesis chemokine (C-C motif) ligand 5 signaling pathway positive regulation of T cell proliferation neutrophil activation regulation of programmed cell death negative regulation by host of viral transcription cellular response to fibroblast growth factor stimulus negative regulation of viral genome replication positive regulation of neuron differentiation positive regulation of osteoclast differentiation negative regulation of G-protein coupled receptor protein signaling pathway positive regulation of G-protein coupled receptor protein signaling pathway positive regulation of angiogenesis positive regulation of cell adhesion eosinophil chemotaxis lymphocyte chemotaxis positive regulation of smooth muscle cell proliferation positive regulation of epithelial cell proliferation regulation of insulin secretion regulation of T cell activation positive chemotaxis positive regulation of protein kinase B signaling positive regulation of calcium ion transport positive regulation of mast cell chemotaxis antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway negative regulation of chemokine-mediated signaling pathway negative regulation of T cell apoptotic process positive regulation of T cell apoptotic process ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of monocyte chemotaxis cellular response to virus positive regulation of neuroinflammatory response positive regulation of STAT cascade negative regulation of macrophage apoptotic process positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of T cell migration positive regulation of natural killer cell chemotaxis dendritic cell chemotaxis monocyte chemotaxis regulation of chronic inflammatory response chemotaxis response to virus positive regulation of viral genome replication positive regulation of innate immune response positive regulation of translational initiation macrophage chemotaxis receptor signaling pathway via STAT chronic inflammatory response response to xenobiotic stimulus response to bacterium response to salt stress response to activity dibenzo-p-dioxin metabolic process response to nutrient levels response to lipopolysaccharide response to insulin response to estrogen response to glucocorticoid response to cholesterol cellular response to lipopolysaccharide cellular response to amino acid stimulus cellular response to vitamin K cellular response to morphine cellular response to cytokine stimulus cellular response to ethanol cellular response to lipid cellular response to high density lipoprotein particle stimulus cellular response to alkyl hydroperoxide cellular response to transforming growth factor beta stimulus response to alcohol
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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