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Product Details
710042
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
Expi293
Class
Recombinant Superclonal
Type
Antibody
Clone
4HCLC
Immunogen
Protein corresponding to amino acids 30-212 of human IL-6
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
Target Information
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; H-IL-6; Hybridoma growth factor; hybridoma growth factor peptide; IFN-beta-2; IL-6; IL6; ILN; interferon 6 precursor; Interferon beta-2; Interleukin; interleukin 6; interleukin BSF-2; Interleukin-6; Interleukin6; M-IL-6; R-IL-6; unnamed protein product
Gene Aliases: BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6; IL6
UniProt ID: (Human) P05231
Entrez Gene ID: (Human) 3569
neutrophil apoptotic process
germinal center B cell differentiation
hepatic immune response
neutrophil mediated immunity
monocyte chemotaxis
positive regulation of immunoglobulin production
positive regulation of acute inflammatory response
positive regulation of leukocyte chemotaxis
acute-phase response
inflammatory response
immune response
humoral immune response
JAK-STAT cascade
positive regulation of cell proliferation
negative regulation of cell proliferation
vascular endothelial growth factor production
regulation of vascular endothelial growth factor production
positive regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
negative regulation of lipid storage
response to activity
cytokine-mediated signaling pathway
cell differentiation
platelet activation
endocrine pancreas development
neuron projection development
response to peptidoglycan
negative regulation of chemokine production
positive regulation of chemokine production
positive regulation of interleukin-1 beta production
positive regulation of interleukin-10 production
positive regulation of interleukin-17 production
positive regulation of interleukin-21 production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
positive regulation of tumor necrosis factor production
negative regulation of collagen biosynthetic process
positive regulation of peptidyl-serine phosphorylation
maintenance of blood-brain barrier
positive regulation of T cell proliferation
glucose homeostasis
positive regulation of apoptotic process
negative regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of fat cell differentiation
positive regulation of osteoblast differentiation
positive regulation of translation
regulation of angiogenesis
negative regulation of bone resorption
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
regulation of insulin secretion
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of B cell activation
regulation of protein transport
positive regulation of lymphocyte activation
response to glucocorticoid
defense response to virus
positive regulation of glial cell proliferation
T follicular helper cell differentiation
regulation of astrocyte activation
neuron cellular homeostasis
glucagon secretion
regulation of glucagon secretion
interleukin-6-mediated signaling pathway
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
T-helper 17 cell lineage commitment
hepatocyte proliferation
positive regulation of extracellular matrix disassembly
inflammatory response to wounding
liver regeneration
receptor signaling pathway via STAT
cellular response to virus
regulation of neuroinflammatory response
positive regulation of neuroinflammatory response
positive regulation of cytokine production involved in inflammatory response
positive regulation of platelet aggregation
positive regulation of apoptotic DNA fragmentation
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
regulation of microglial cell activation
positive regulation of STAT cascade
positive regulation of leukocyte adhesion to vascular endothelial cell
positive regulation of T-helper 2 cell cytokine production
negative regulation of primary miRNA processing
negative regulation of interleukin-1-mediated signaling pathway
positive regulation of type B pancreatic cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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