Search
Invitrogen
STAT4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
71-4500
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide derived from the extreme carboxy-terminus of murine STAT4.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.25 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein is most similar to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 is similar to other STAT family members in that it can be tyrosine phosphorylated by Jak1 or Jak2. STAT4 forms homodimers and heterodimers with related STAT family members. Tyrosine phosphorylated STAT4 can bind the IFN-gamma activated site (GAS). Serine phosphorylation of STAT is also required for maximal transcriptional activity. STAT4 expression is restricted to the thymus, spleen and testis. Until recently the cytokine(s) responsible for activation of STAT4 had not been identified. STAT4 is now known to be activated by the cytokine interleukin 12 (IL-12). IL-12 is required for the T-cell independent induction of IFN-gamma which is a key step in the initial suppression of bacterial and parasitic infections. In addition, IL-12 is required for the development of a Th1 response which is necessary for effective host defense against intracellular pathogens. STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells. A recent study in mouse has shown that in response to viral infection IFN-a/b activation of STAT4 is required for IFN-g production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CIS4; HSPC060; OTTHUMP00000163553; SOCS4; SOCS6; SSI4; STAI4; STAT; STATI4; unnamed protein product
Gene Aliases: DPMC; SLEB11
UniProt ID: (Human) Q14765, (Mouse) P42228
Entrez Gene ID: (Human) 6775, (Mouse) 20849, (Rat) 367264
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
identical protein binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcription corepressor binding
transcription coactivator binding
double-stranded DNA binding
tumor necrosis factor receptor binding
enzyme binding
CCR5 chemokine receptor binding
histone acetyltransferase binding
histone binding
protein homodimerization activity
ubiquitin-like protein ligase binding
protein phosphatase 2A binding
promoter-specific chromatin binding
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
defense response
signal transduction
JAK-STAT cascade
cell proliferation
positive regulation of gene expression
cytokine-mediated signaling pathway
interleukin-12-mediated signaling pathway
regulation of cell proliferation
response to peptide hormone
T-helper 1 cell differentiation
positive regulation of transcription from RNA polymerase II promoter
hematopoietic stem cell homeostasis
response to interleukin-6
immune response
negative regulation of endothelial cell proliferation
positive regulation of defense response to virus by host
transcription, DNA-templated
response to nutrient
blood circulation
biological_process
positive regulation of cell proliferation
response to xenobiotic stimulus
response to mechanical stimulus
response to bacterium
negative regulation of angiogenesis
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
positive regulation of interferon-alpha production
cellular response to insulin stimulus
tumor necrosis factor-mediated signaling pathway
response to cytokine
negative regulation of macrophage fusion
response to type I interferon
response to interferon-gamma
response to interferon-beta
cellular response to interferon-beta
interleukin-7-mediated signaling pathway
interleukin-9-mediated signaling pathway
response to hydrogen peroxide
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to exogenous dsRNA
endothelial cell migration
positive regulation of nitric oxide biosynthetic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
negative regulation by virus of viral protein levels in host cell
positive regulation of smooth muscle cell proliferation
negative regulation of developmental process
response to cAMP
defense response to virus
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
renal tubule development
interleukin-27-mediated signaling pathway
cellular response to lipopolysaccharide
cellular response to interferon-gamma
receptor signaling pathway via STAT
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support