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Invitrogen
Kindlin Polyclonal Antibody
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FIGURE: 1 / 3
Kindlin Antibody (720123) in WB
Western blot analysis was performed on whole cell extracts (30 µg lysate) of A-431 (Lane 1), HT-29 (Lane 2), and HCT 116 (Lane 3). The blots were probed with Polyclonal Kindlin Antibody (Product # 720123, 1-2 µg/mL) and detected by chemiluminescence using Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, HRP conjugate (Product # A27036, 0.4 µg/mL, 1:2500 dilution). A 77, 63 and 56 kDa bands corresponding to Kindlin was observed. Known quantity of protein samples were electrophoresed using Novex® NuPAGE® 10% Bis-Tris gel (... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
720123
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Protein corresponding to Human FERMT1 (aa 110-320)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 30% glycerol, 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Cat and Bovine.
Target Information
Kindlin 1 is a member of the kindlin family of focal adhesion proteins and contains a FERM domain and pleckstrin homology domain. It is involved in integrin signaling, linkage of the cytoskeleton to the extracellular matrix, and cell adhesion. It is most often expressed in epithelial cells. When kindlin 1 is coexpressed with talin it helps to activate ITGA2B. It is required for keratinocyte proliferation, polarization of basal keratinocytes in the skin, and for normal cell shape. Mutations in kindlin 1 have been linked to Kindler syndrome, a recessive skin disorder involving blistering, photosensitivity, poikiloderma, and atrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: fermitin family member 1; FLJ20116; FLJ23423; kindlerin; kindlin 1; kindlin syndrome protein; RP5-1056H1.1; similar to Caenorhabditis elegans Unc-112 related protein 1; unc-112-related protein 1; UNC112 related protein 1; unnamed protein product
Gene Aliases: C20orf42; DTGCU2; KIND1; UNC112A; URP1
UniProt ID: (Human) Q9BQL6
Entrez Gene ID: (Human) 55612
positive regulation of cell-matrix adhesion
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of gene expression
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
positive regulation of integrin activation
positive regulation of cell adhesion mediated by integrin
negative regulation of protein import into nucleus
keratinocyte proliferation
keratinocyte migration
negative regulation of timing of anagen
positive regulation of transforming growth factor beta production
basement membrane organization
negative regulation of canonical Wnt signaling pathway
establishment of epithelial cell polarity
positive regulation of wound healing, spreading of epidermal cells
negative regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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