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Invitrogen

DRD1 Polyclonal Antibody

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View all (21) DRD1 antibodies

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DRD1 Polyclonal Antibody

Product Details

720276

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide corresponding to Human DRD1 (aa 164-179)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2-7.4, with 0.1% BSA, 30% glycerol

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2633231

Product Specific Information

These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.

This antibody is predicted to react with Monkey, Cat, Bovine and Pig.

Target Information

The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: D1 receptor; D1A dopamine receptor; D1a receptor; Dopamine 1 receptor; dopamine D1 receptor; dopamine receptor D1A; Dopamine-1A receptor; DRD1; G protein-coupled receptor DRD1; G-protein coupled receptor; unnamed protein product

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Gene Aliases: C030036C15Rik; D1a; D1R; DADR; Drd-1; DRD1A; Gpcr15

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UniProt ID: (Human) P21728, (Mouse) Q61616

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Entrez Gene ID: (Human) 1812, (Rat) 24316, (Mouse) 13488

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Function(s)
dopamine neurotransmitter receptor activity, coupled via Gs G-protein alpha-subunit binding G-protein coupled receptor activity dopamine neurotransmitter receptor activity protein binding heterotrimeric G-protein binding dopamine binding arrestin family protein binding G-protein coupled serotonin receptor activity receptor binding protein phosphatase binding neurotransmitter receptor activity angiotensin receptor binding D3 dopamine receptor binding macromolecular complex binding ATPase binding heterocyclic compound binding
Process(es)
temperature homeostasis conditioned taste aversion behavioral fear response regulation of protein phosphorylation positive regulation of protein phosphorylation synaptic transmission, dopaminergic response to amphetamine protein phosphorylation negative regulation of protein kinase activity protein import into nucleus intracellular protein transport muscle contraction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-modulating G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity adenylate cyclase-activating dopamine receptor signaling pathway dopamine receptor signaling pathway chemical synaptic transmission synapse assembly learning memory mating behavior grooming behavior locomotory behavior adult walking behavior feeding behavior associative learning visual learning response to xenobiotic stimulus astrocyte development response to activity transmission of nerve impulse neuronal action potential regulation of vasoconstriction calcium-mediated signaling dentate gyrus development striatum development hippocampus development orbitofrontal cortex development cerebral cortex GABAergic interneuron migration positive regulation of cell migration negative regulation of cell migration peristalsis response to food response to estradiol response to retinoic acid cellular response to insulin stimulus response to nicotine operant conditioning social behavior regulation of locomotion regulation of dopamine metabolic process response to cocaine vasodilation negative regulation of circadian sleep/wake cycle, sleep maternal behavior eating behavior response to amino acid regulation of ion transport response to ethanol positive regulation of membrane potential habituation sensitization behavioral response to cocaine regulation of synaptic plasticity response to steroid hormone negative regulation of synaptic transmission positive regulation of release of sequestered calcium ion into cytosol positive regulation of synaptic transmission, glutamatergic phospholipase C-activating dopamine receptor signaling pathway long-term synaptic potentiation long term synaptic depression cellular response to hypoxia cellular response to catecholamine stimulus G protein-coupled serotonin receptor signaling pathway glucose import across plasma membrane modification of postsynaptic structure postsynaptic modulation of chemical synaptic transmission presynaptic modulation of chemical synaptic transmission negative regulation of cellular response to hypoxia positive regulation of long-term synaptic potentiation positive regulation of feeding behavior phospholipase C-activating G-protein coupled receptor signaling pathway dopamine metabolic process positive regulation of potassium ion transport positive regulation of MAPK cascade regulation of dopamine uptake involved in synaptic transmission adenylate cyclase-activating adrenergic receptor signaling pathway negative regulation of behavioral fear response
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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