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Thyroid Hormone Receptor Beta1 Monoclonal Antibody (N402/46)
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Product Details
75-387
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
N402/46
Immunogen
Fusion protein amino acids 1-461 (full-length) of human Thyroid hormone receptor beta1 (accession number P10828) produced recombinantly in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
TBS, pH 7.4
Contains
0.065% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Dry ice (international)
Product Specific Information
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Target Information
Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone. Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha-1 and TRv alpha-2, and TR beta-1 and TR beta-2 respectively. TR alpha-1 and 2 are identical through amino acid 370 where their sequences diverge. TRv alpha-2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha-1. The corresponding gene for the thyroid hormone receptor beta-1 is NR1A2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-erbA-2; c-erbA-beta; ERBA 2; ERBA BETA; ERBA-BETA; MGC126109; MGC126110; nuclear receptor; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; Thyroid hormone receptor beta; thyroid hormone receptor beta 3; thyroid hormone receptor beta2delta; thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2); thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR; TR beta; TR beta 1; TR-B1C-ERBA-2; TRbeta2Delta; unnamed protein product
Gene Aliases: C-ERBA-2; C-ERBA-BETA; c-erbAbeta; ERBA2; GRTH; NR1A2; PRTH; RATT3REC; T3R[b]; T3Rbeta; T3rec; THR1; THRB; THRB1; THRB2; THRbeta; THRbeta1; Thrbeta2; TRb; TRbeta; TRbeta1
UniProt ID: (Human) P10828, (Mouse) P37242
Entrez Gene ID: (Human) 7068, (Mouse) 21834, (Rat) 24831
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
enzyme binding
chromatin DNA binding
sequence-specific DNA binding
metal ion binding
thyroid hormone binding
sequence-specific double-stranded DNA binding
double-stranded DNA binding
steroid hormone receptor activity
thyroid hormone receptor activity
protein homodimerization activity
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
thyroid hormone mediated signaling pathway
positive regulation of thyroid hormone receptor signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
sensory perception of sound
negative regulation of female receptivity
regulation of heart contraction
female courtship behavior
organ morphogenesis
cell differentiation
mRNA transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinal cone cell development
retinoic acid receptor signaling pathway
Type I pneumocyte differentiation
cellular response to thyroid hormone stimulus
retinal cone cell apoptotic process
transcription from RNA polymerase II promoter
positive regulation of cell proliferation
regulation of lipid metabolic process
intracellular receptor signaling pathway
positive regulation of chondrocyte differentiation
steroid hormone mediated signaling pathway
positive regulation of ossification
regulation of cholesterol metabolic process
regulation of triglyceride metabolic process
embryonic organ development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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