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NeoBiotechnologies
14-3-3E/Tryptophan 5-Monooxygenase Monoclonal Antibody (CPTC-YWHAE-1)
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Product Details
7531-MSM1-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
CPTC-YWHAE-1
Immunogen
Recombinant human full-length YWHAE protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
14-3-3 epsilon belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 epsilon; 14-3-3 protein epsilon; 14-3-3E; epididymis luminal protein 2; mitochondrial import stimulation factor L subunit; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, epsilon polypeptide; unnamed protein product
Gene Aliases: 14-3-3E; HEL2; KCIP-1; MDCR; MDS; YWHAE
UniProt ID: (Human) P62258
Entrez Gene ID: (Human) 7531
RNA binding
protein phosphatase inhibitor activity
calcium channel regulator activity
protein binding
potassium channel regulator activity
calcium channel inhibitor activity
enzyme binding
protein phosphatase binding
protein domain specific binding
MHC class II protein complex binding
ubiquitin protein ligase binding
signaling adaptor activity
identical protein binding
histone deacetylase binding
ion channel binding
cadherin binding
protein heterodimerization activity
phosphoserine binding
phosphoprotein binding
scaffold protein binding
protein sequestering activity
molecular function inhibitor activity
MAPK cascade
neuron migration
cytoplasmic pattern recognition receptor signaling pathway
regulation of heart rate by hormone
protein targeting
ER to Golgi vesicle-mediated transport
Golgi to plasma membrane transport
signal transduction
regulation of mitotic cell cycle
protein localization
substantia nigra development
hippocampus development
cerebral cortex development
cellular potassium ion homeostasis
negative regulation of toll-like receptor signaling pathway
positive regulation of toll-like receptor signaling pathway
toll-like receptor 4 signaling pathway
protein localization to nucleus
cellular response to heat
hippo signaling
positive regulation of hippo signaling
intracellular signal transduction
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of protein export from nucleus
regulation of cytosolic calcium ion concentration
regulation of membrane repolarization
protein localization to endoplasmic reticulum
protein K11-linked ubiquitination
membrane repolarization during cardiac muscle cell action potential
regulation of heart rate by cardiac conduction
regulation of potassium ion transmembrane transport
negative regulation of calcium ion export across plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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