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NeoBiotechnologies
PAX8 (Renal Cell Marker) Recombinant Rabbit Monoclonal Antibody (PAX8/8651R)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
7849-RBM17-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
PAX8/8651R
Immunogen
Recombinant fragment (around aa150-300) of human PAX8.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:HeLa or Raji cells. Human renal cell carcinoma (RCC) or ovarian serous carcinoma.
Cellular Location: Nucleus.
Target Information
This gene encodes a member of the paired box family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:8622; paired domain gene 8; paired-box-protein; PAX8d; PAX8e; PAX8F; unnamed protein product
Gene Aliases: PAX-8
UniProt ID: (Human) Q06710
Entrez Gene ID: (Human) 7849
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
thyroid-stimulating hormone receptor activity
protein binding
sequence-specific double-stranded DNA binding
urogenital system development
metanephros development
branching involved in ureteric bud morphogenesis
kidney development
mesonephros development
ventricular septum development
mesenchymal to epithelial transition involved in metanephros morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
nervous system development
central nervous system development
sensory organ development
anatomical structure morphogenesis
negative regulation of cardiac muscle cell apoptotic process
cell differentiation
thyroid gland development
thyroid-stimulating hormone signaling pathway
pronephric field specification
inner ear morphogenesis
regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
pronephros development
ureteric bud morphogenesis
cellular response to gonadotropin stimulus
otic vesicle development
S-shaped body morphogenesis
kidney epithelium development
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
mesonephric tubule development
metanephric collecting duct development
metanephric epithelium development
metanephric distal convoluted tubule development
metanephric nephron tubule development
metanephric comma-shaped body morphogenesis
metanephric S-shaped body morphogenesis
metanephric nephron tubule formation
positive regulation of metanephric DCT cell differentiation
positive regulation of thyroid hormone generation
regulation of thyroid-stimulating hormone secretion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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