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7TM Antibodies
SST5, Somatostatin Receptor 5 Polyclonal Antibody
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FIGURE: 1 / 7
SST5, Somatostatin Receptor 5 Antibody (7TM0359N-IC) in IHC (P)
Immunohistochemical identification of Somatostatin Receptor 5 in human pancreatic islets. Sections were dewaxed, microwaved in citric acid, and incubated with anti-SST5 (Somatostatin Receptor 5) antibody (7TM0359N-IC) at a dilution of 1:100. Sections were then sequentially treated with biotinylated anti-rabbit IgG and avidin-biotin solution. Color was developed by incubation in AEC, and sections were counte... View More
Product Details
7TM0359N-IC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide with sequence QEATPPAHRAAANGLMQTSKL corresponds to amino acids 344 - 364 of human SST5.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Somatostatin is a multifunctional protein affecting exocrine and endocrine protein secretion, neurotransmission, and neuronal modulation and regulating cell proliferation. All these functions of Somatostatin are executed through a class of GPCR protein family members called somatostatin receptor. Till date, 6 classes of somatostatin receptors have been discovered out of which SSTR5, 364A.A protein, is a receptor subtype expressed predominantly in the pituitary and hypothalamus region of brain. Studies revealed that SSTR5 contains seven transmembrane regions and undergoes homodimerization and also heterodimerizes with SSTR1. Although the specific functions of SSTR5 are still elusive, the studies indicate that it complements SSTR2 regulation of ACTH secretion. Polymorphisms in SSTR5 gene have been observed in patients with acromegaly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: membrane receptor; SSTR5B; membrane receptor; SSTR5C; somatostatin receptor; somatostatin receptor subtype 5; Somatostatin receptor type 5; SS-5-R
Gene Aliases: SS-5-R; SST5; SSTR5
UniProt ID: (Human) P35346
Entrez Gene ID: (Human) 6755
signal transduction
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
neuropeptide signaling pathway
negative regulation of cell proliferation
positive regulation of cytokinesis
somatostatin signaling pathway
glucose homeostasis
regulation of insulin secretion
cellular response to glucocorticoid stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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