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Proteintech
NLRP10 Recombinant Rabbit Monoclonal Antibody (230402C1)
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Product Details
83131-8-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
230402C1
Immunogen
NLRP10 fusion protein Ag26402
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MAMAKARKPR EALLWALSDL EENDFKKLKF YLRDMTLSEG QPPLARGELE GLIPVDLAEL LISKYGEKEA VKVVLKGLKV MNLLELVDQL SHICLHDYRE VYREHVRCLE EWQEAGVNGR YNQVLLVAKP SSESPESLAC PFPEQELESV TVEALFDSGE KPSLAPSLVV LQGSAGTGKT
Target Information
NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1-b, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1-b processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apaf-1-like protein; pyrin-like domain- and nucleotide-binding and oligomerization domain-containing protein; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; neuronal apoptosis inhibitor protein 10; Nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10
Gene Aliases: 6430548I20Rik; CLR11.1; NALP10; Napl10; NLRP10; NOD8; PAN5; PYNOD
UniProt ID: (Human) Q86W26, (Mouse) Q8CCN1
Entrez Gene ID: (Human) 338322, (Mouse) 244202
immune system process
positive regulation of T-helper 1 type immune response
defense response
helper T cell enhancement of adaptive immune response
dendritic cell migration
innate immune response
defense response to Gram-negative bacterium
defense response to fungus
positive regulation of T-helper 17 type immune response
positive regulation of interleukin-8 secretion
positive regulation of interleukin-6 secretion
activation of innate immune response
adaptive immune response
inflammatory response
positive regulation of defense response
positive regulation of interleukin-1 alpha production
positive regulation of interleukin-6 production
positive regulation of interleukin-8 production
regulation of inflammatory response
positive regulation of inflammatory response
positive regulation of immune response
positive regulation of defense response to bacterium
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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