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Proteintech
MAGI2 Recombinant Rabbit Monoclonal Antibody (240512C10)
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Product Details
83561-6-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293F
Class
Recombinant Monoclonal
Type
Antibody
Clone
240512C10
Immunogen
MAGI2 fusion protein Ag18279
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence:
DRPPHSLHS MPTDGQLDGT YPPPVHDDNV SMASSGATQA ELMTLTIVKG AQGFGFTIAD SPTGQRVKQI LDIQGCPGLC EGDLIVEINQ QNVQNLSHTE VVDILKDCPI GSETSLIIHR GGFFSPWKTP KPIMDRWENQ GSPQTSLSAP AIPQNLPFPP ALHRSSFPDS TEAFDPRKPD PYELYEKSRA IYESRRPDYK ELDVHLRRME SGFGFRILGG DEPGQPILIG AVIAMGSADR DGRLHPGDEL VYVDGIPVAG KTHRYVIDLM HHAARNGQVN LTVRRKVLCG GEPCPENGRS PGSVSTHHSS PRSDYATYTN SNHAAPSSNA SPPEGFASHS LQTSDVVIHR K
Target Information
Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. The MGC Project Team, Genome Res. 14:2121-2127(2004). Devroe E., J. Biol. Chem. 279:24444-24451(2004).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin receptor interacting protein 1; AIP-1; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGUK-like protein with 5 PDZ domains, 2 WW domains and a guanylate kinase-like domain; Membrane-associated guanylate kinase inverted 2; Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; S-SCAM; Synaptic-scaffolding molecule; unnamed protein product
Gene Aliases: ACVRINP1; ACVRIP1; AIP-1; AIP1; ARIP1; KIAA0705; MAGI-2; MAGI2; NPHS15; S-SCAM; SSCAM
UniProt ID: (Human) Q86UL8, (Rat) O88382
Entrez Gene ID: (Human) 9863, (Rat) 113970
positive regulation of receptor internalization
endocytosis
signal transduction
nervous system development
negative regulation of cell proliferation
positive regulation of neuron projection development
negative regulation of cell migration
negative regulation of activin receptor signaling pathway
nerve growth factor signaling pathway
receptor clustering
negative regulation of protein kinase B signaling
Wnt signaling pathway, planar cell polarity pathway
SMAD protein signal transduction
glomerular visceral epithelial cell development
clathrin-mediated endocytosis
cellular response to nerve growth factor stimulus
glomerular filtration
phosphorylation
cytosolic transport
positive regulation of phosphoprotein phosphatase activity
protein heterooligomerization
mitotic cell cycle arrest
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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