KaryoStat™ HD Assay
KaryoStat™ HD Assay
Applied Biosystems™

KaryoStat™ HD Assay

The KaryoStat HD Assay offers genotyping (sample ID) plus high resolution whole-genome coverage for accurate detection of chromosomal abnormalities. TheRead more
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Catalog number 905404
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The KaryoStat HD Assay offers genotyping (sample ID) plus high resolution whole-genome coverage for accurate detection of chromosomal abnormalities. The assay has greater than 99% sensitivity and can reliably detect 25–50 kb copy number changes across the genome at high specificity with single-nucleotide polymorphism (SNP) allelic corroboration. These high-density SNPs enable low-level mosaicism visualization and absence of heterozygosity (AOH), copy number change, and genomic contamination identification for research use. With more than 2.6 million copy number markers, the KaryoStat HD Assay covers all OMIM™ and RefSeq genes. Our proprietary manufacturing technology produces arrays that are highly reproducible between each batch with no risk of probe dropout inherent in bead manufacturing techniques. The assay includes arrays, reagents, and easy-to-use data analysis software for a cost-effective and streamlined analysis of pluripotent stem cell lines.

Features include:
• Broadest coverage and highest performance for detecting chromosomal abnormalities
• Karyotyping and genotyping (sample ID) with one assay
• >99% sensitivity and can reliably detect 25–50 kb copy number changes
• Simple analysis; no cytogenetics expertise necessary
• Assay includes arrays, reagents, and free downloadable software
• 2.5 days to results

 KaryoStat AssayKaryoStat HD Assay
Gains>2 Mb>25–50 kb
Losses>1 Mb>25–50 kb
Absence of heterozygosity>5 Mb>1 Mb
SNPYesYes
CoverageLowHighest
InstrumentGeneChip Scanner 3000 onlyGeneChip Scanner 3000 only
Analysis softwareChromosomal Analysis SuiteChromosomal Analysis Suite
Specifications
TypeHD Assay
Number of Arrays24 arrays
FormatGenechip Probe Array
SpeciesHuman
For Use With (Equipment)GeneChip Scanner 3000
IncludesArrays, Reagents, Data Analysis Software
Product LineKaryoStat™ HD
Quantity24 assays
Shipping ConditionApproved for shipment at Room Temperature or on Wet or Dry Ice
Unit SizeEach
Contents & Storage
Store at 2–8°C:
• Arrays
• Module 2: Pre-Lab TE Buffer and Water
• Module 4: Main Lab Stain, Holding Buffer, Beads, and Water

Store at -5 to -30°C:
• Module 3: Main Lab Fragmentation, Labeling, and Hybridization

Store at room temperature:
• Module 5: Main Lab Elution Buffer
• Purification Wash Buffer
• Wash Buffer A
• Wash Buffer B