LRRK2 G2019S Full Length Protein

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Description

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.

Increase disease relevance by interrogating a purified and active full-length LRRK2 protein
Uncover novel compounds or hits specific to the full-length form
Advance Parkinson's research using the full-length protein and validated assays

Related Links:
LRRK2 tools for advancing Parkinson's disease research
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For Research Use Only. Not for use in diagnostic procedures.

Specifications

Accession Number: NP_940980.3
Expression: Mammalian
Gene Aliases: AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Kinase Family: LRRK Kinase Family
Molecular Weight: 288 kDa
Product Size: 10 µg
Protein Form: Full Length
Protein Tag or Fusion: DYKDDDDK
Research Category: Neurobiology
Species: Human
Validated Application: Kinase Assay

Contents & storage

Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. If properly stored, this product is guaranteed for 6 months from date of purchase.

Suspended in: 50 mM Tris (pH 7.5), 150 mM NaCl, 0.5 mM EDTA, 0.02% Triton®X–100, 2 mM DTT, and 50% glycerol.