Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene, which codes for a multidomain protein kinase, are considered the most common genetic cause of late-onset autosomal-dominant Parkinson's disease. This full-length, purified and active LRRK2 G2019S mutant protein may be useful in research to better understand the most common Parkinson's disease-relevant mutant, as well as to explore the mechanisms underlying the disease.
• Increase disease relevance
by interrogating a purified and active full-length LRRK2 protein
• Uncover novel compounds
or hits specific to the full-length form
• Advance Parkinson's research
using the full-length protein and validated assaysRelated Links:
• LRRK2 tools for advancing Parkinson's disease research
• Kinase protein portfolio
• LanthaScreen™ Eu Kinase Binding Assay
• LanthaScreen™ TR-FRET Kinase Activity Assay
For Research Use Only. Not for use in diagnostic procedures.