Search
Invitrogen
CD51 Monoclonal Antibody (13C2), PE
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation'] || 'Additional Information'}}:
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
A15458
Product Specifications
Species Reactivity
Bovine,
Human,
Non-human primate,
Rabbit
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
13C2
Immunogen
human CD51 from Cell suspension containing osteoclasts from osteoclastomas
Conjugate
PE
PE
PE
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS, pH 7.5
Contains
<0.1% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: alpha-v integrin; antigen identified by monoclonal antibody L230; integrin; integrin alpha V subunit; integrin alphaVbeta3; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); unnamed protein product; vitronectin alpha subunit precursor; vitronectin receptor subunit alpha
Gene Aliases: CD51; IDNDC; MSK8; VNRA; VTNR
UniProt ID: (Bovine) P80746, (Human) P06756
Entrez Gene ID: (Bovine) 281875, (Rabbit) 100008956, (Human) 3685
virus receptor activity
metal ion binding
opsonin binding
fibronectin binding
protease binding
protein kinase C binding
receptor binding
integrin binding
protein binding
coreceptor activity
fibroblast growth factor binding
C-X3-C chemokine binding
insulin-like growth factor I binding
signaling receptor activity
neuregulin binding
transforming growth factor beta binding
extracellular matrix binding
extracellular matrix protein binding
integrin
blood vessel development
integrin-mediated signaling pathway
cell adhesion mediated by integrin
viral entry into host cell
regulation of transforming growth factor beta activation
angiogenesis
vasculogenesis
formation of primary germ layer
cell adhesion
cell-matrix adhesion
positive regulation of cytosolic calcium ion concentration
positive regulation of cell proliferation
tissue development
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
negative regulation of low-density lipoprotein particle clearance
cell migration
positive regulation of cell migration
cell-substrate adhesion
negative regulation of lipid transport
positive regulation of osteoblast proliferation
heterotypic cell-cell adhesion
substrate adhesion-dependent cell spreading
wound healing, spreading of epidermal cells
endodermal cell differentiation
apolipoprotein A-I-mediated signaling pathway
apoptotic cell clearance
positive regulation of cell adhesion
negative regulation of lipoprotein metabolic process
regulation of phagocytosis
negative chemotaxis
positive regulation of small GTPase mediated signal transduction
ERK1 and ERK2 cascade
calcium ion transmembrane transport
transforming growth factor beta production
entry into host cell by a symbiont-containing vacuole
extrinsic apoptotic signaling pathway in absence of ligand
cell-cell adhesion
positive regulation of intracellular signal transduction
negative regulation of entry of bacterium into host cell
negative regulation of extrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support